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A particular class of medication used to treat high blood pressure could protect older adults against memory decline and other impairments in cognitive function, according to a newly published study from Wake Forest University School of Medicine.
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A team of researchers, at the Genome Institute of Singapore, has identified a new gene that seems to contribute to aggressive breast cancer behavior. As discussed in an accompanying commentary, by Gordon Mills and colleagues, the data generated in this study provide new insight into cellular processes underlying tumor cell proliferation and metastasis and identify potential new therapeutic targets. Drugshop to buy zoloft online and other pills.
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Shedding Light On Social Brain Development
The capacity to figure out what others are thinking and what they mean is an ability unique to people that"s central to our lives. A new study on the neural mechanisms that govern these abilities sheds light on the relation between how people and groups interact, on the one hand, and how the brain develops and functions, on the other.
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A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

UroToday.com - This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum. We also describe CYP17A1 expression in human prostate tissues during castration resistant progression of cancer and identify a subcellular pattern of distribution for CYP17A1 consistent with a secretory protein in human prostate tissues, similar to that of PSA. Amongst the numerous proteins shown to be present in prostasomes we have found this key steroidogenic enzyme involved in testosterone synthesis from cholesterol. CYP17A1 is currently a target of investigational agents such as Abiraterone, which is under investigation for the treatment of advanced castration resistant disease. We postulate that this phenomenon is a cellular response triggered by upregulation of processes required for the cell to undergo cholesterol mediated steroid synthesis to testosterone and DHT within prostate tumour cells and is an adaptive resistance mechanism to depletion of androgens. Despite our inability to demonstrate metabolic enzyme activity in exosome isolates, we believe that CYP17A1 presence in the serum and its elevation in cancer patients compared with healthy controls suggests that it may be a novel diagnostic biomarker. Beyond its potential as a biomarker we propose that CYP17A1 could be playing a communication role in castrate resistant cancer development. In the absence of a supply of testicular androgens, when mechanisms involved in de novo androgen synthesis have been shown to be activated1, exosomal "life-rafts" are released from the cell, loaded with "adaptive survival messages" for other cells to host and potentially assimilate in order to enhance chances of survival. This hypothesis works on the basis that elevated cholesterol levels are observed in cancer cells during castration resistant development, which in turn has been shown to regulate an increase in the extrusion of prostate derived exosomes into the cancer microenvironment2, triggers the release of these "exosomal "life rafts". References: 1. Locke J, Guns ES, Lubik A, Adomat H, Hendy S, Wood C, Gleave ME, Nelson CC: De Novo Synthesis of Androgens as a Potential Mechanism behind Androgen-Independent Prostate Cancer Progression. Cancer Res. 2008 Aug 1;68(15):6407-15 2. Llorente A, van Deurs, B and Sandvig, K: Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells. European Journal of Cell Biology 86 (2007) 405-415 Manuscript: Locke J, Fazli L, Adomat H, Smyl J, Weins K, Barr S, Lubik A, Hales B, Nelson CC, Gleave M and Tomlinson Guns ES: CYP17A1 is elevated in the serum of prostate cancer patients as compared to healthy controls. Prostate Mar 2009 [EPub ahead of print] Written by Emma Tomlinson Guns, PhD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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