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PTSD Associated With Higher Alzheimer's/Dementia Risk; Moderate Alcohol Consumption May Lower It
Though discoveries about Alzheimer"s disease risk factors are often in the news, adults do not know about the relationship between Alzheimer"s disease risk and heart health, nor that physical activity can be protective against dementia, according to new research reported today at the Alzheimer"s Association 2009 International Conference on Alzheimer"s Disease (ICAD 2009) in Vienna.
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Half A Million People In The UK Have Undiagnosed Coeliac Disease
Half a million people in the UK have undiagnosed coeliac disease Purchase zoloft to treat depression.
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How Neuronal Activity Is Timed In The Brain's Memory-Making Circuits
Theta oscillations are a type of prominent brain rhythm that orchestrates neuronal activity in the hippocampus, a brain area critical for the formation of new memories. For several decades these oscillations were believed to be "in sync" across the hippocampus, timing the firing of neurons like a sort of central pacemaker. A new study conducted by researchers at the California Institute of Technology (Caltech) argues that this long-held assumption needs to be revised. In a paper published in this week"s issue of the journal Nature, the researchers showed that instead of being in sync, theta oscillations actually sweep along the length of the hippocampus as traveling waves.
Endocrinology

A Potential Targeting Gene Therapy For Developing HCV

Gene therapy has emerged as a novel approach to combat HCV infection in the last few years. However, one of the most important obstacles to overcome is "targeting": the appropriate genes must be delivered and expressed in HCV infected hepatocytes without harming normal tissues. A research article published in the World Journal of Gastroenterology addresses this issue. The research team led by Professor Feng from Central South University cloned the 2"-5"oligoadenylate synthetase (OAS) promoter and investigated its activity in the HCV-core positive liver cells. Since the role of HCV-core protein in modulating OAS gene expression is very controversial, this article further investigates the relationship of HCV-core protein and OAS promoter in human embryo hepatocyte line L02. They established L02/core cell line that stably expressing HCV-core protein, and demonstrated that HCV core protein activated OAS gene promoter specifically and effectively. Utilization of OAS gene promoter would be an ideal strategy for developing HCV-specific gene therapy. Reference: Wang Y, Mao SS, He QQ, Zi Y, Wen JF, Feng DY. Specific activation of 2"-5"oligoadenylate synthetase gene promoter by hepatitis C virus-core protein: A potential for developing hepatitis C virus targeting gene therapy. World J Gastroenterol 2009; 15(25): 3178-3182 http://www.wjgnet.com/1007-9327/15/3178.asp Correspondence to: De-Yun Feng, Department of Pathology, College of Basic Medical Sciences, Central South University, Changsha 410078, Hunan Province, China. Lin Tian World Journal of Gastroenterology


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