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Insulin Glargine - European Medicines Agency Update On Safety
The European Medicines Agency"s Committee for Medicinal Products for Human Use (CHMP) has concluded that there is no cause for concern of the risk of cancer for people with diabetes on insulin glargine (Lantus).
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World Leaders Must Take Action To Support Commitments To Lower Maternal Mortality, Opinion Piece Says
"I stood up and applauded for women everywhere when I heard the news" that the United Nations Human Rights Council, including the U.S., "recognized maternal death as a human rights issue," CARE President and CEO Helene Gayle writes in an Atlanta Journal-Constitution opinion piece. Gayle writes that governments for the past 15 years "have failed to meet the commitments made and targets set to reduce the more than half a million maternal deaths every year."According to Gayle, preventing maternal death "requires three well-coordinated actions: sustain political leadership, secure adequate res and strengthen health systems." She adds that the resolution "is a positive step" but that it is "only effective if it translates into action." She continues, "It"s great to see the Obama administration places women and girls high on the agenda," adding that many members of Congress also support these issues.Reducing maternal mortality "requires significant res," Gayle writes. She adds, "To be blunt, an estimated global commitment of $39 billion over 10 years is needed to make significant progress." Such a commitment would be "an investment in women, their families and the economic productivity of nations," according to Gayle."The cost of not investing is far greater," Gayle continues. She notes that women "do two-thirds of the world"s work and produce nearly 60% of the world"s food." In addition, "children who lose their mothers are 10 times more likely to die in childhood than children with mothers," and maternal and newborn deaths "represent an estimated annual loss of $15.5 billion in productivity," according to Gayle. "Clearly, other development goals cannot be met without healthy mothers," she adds.She continues that the "most tragic and infuriating point" is that the "death of a woman in childbirth is one of the most inexcusable deaths on earth." Because high maternal mortality is a "barometer of weak health systems, often reflecting the low status of women," strengthening health systems to improve maternal health will therefore enable the system to "address other health needs," Gayle writes. She adds that countries such as Bangladesh, Ethiopia and Peru have improved mortality rates "through four lifesaving programs: family planning, skilled and culturally sensitive care during pregnancy and childbirth, emergency care for complications and postpartum care."Gayle writes, "The U.S. can spearhead a comprehensive maternal health action plan and, by doing so, set an example for world leaders to join and invest in." She concludes, "The actions we take now can make maternal death a problem of the past and not one of our children"s future" (Gayle, Atlanta Journal-Constitution, 7/10).
Cardiovascular

Exercise Programs Focusing On Muscle Density Could Reduce Disability And Hospitalization Of The Elderly

Older adults who have less strength, poor physical function and low muscle density are at higher risk of being hospitalized compared to adults with more strength and better function. That"s the finding of a new study in the Journal of the American Geriatric Society. The study also found that muscle density, a measure of how much fat compared to lean tissue there is in the muscle, is a more accurate gauge of a person"s risk of hospitalization than muscle mass or size. The relative risk for hospitizations was 50% higher for those with poor walking or less dense muscle mass "Our research suggests that we need to re-think the way we define sarcopenia or age-related muscle loss," says Peggy Cawthon, PhD, MPH, a scientist with the California Pacific Medical Center Research Institute and the lead author of the study. "Many definitions of sarcopenia today tend to focus on lean mass or muscle size, our study shows that is looking at the wrong factors. We found that muscle strength or performance were much better ways of measuring function." The researchers followed 3,011 healthy, non-disabled adults between the ages of 70 and 80, for an average of almost five years. They measured their physical function in a number of ways including walking speed, their ability to stand up from a chair repeatedly, the strength of their grip and their leg strength. By the end of the study more than 55 percent of the participants had experienced one or more hospitalizations. Those most likely to end up in the hospital were the adults who scored lowest on the measures of physical function; this held true after allowing age, medical conditions, lean mass or muscle size. They also found that adults with the least dense thigh muscles, namely those with a higher proportion of fat in their thighs, were also at a higher risk of hospitalization compared to adults with more dense thighs. "The findings are particularly important because they suggest that interventions, such as physical exercise, that improve physical function could help keep more vulnerable seniors out of the hospital," says Cawthon. "That would not only reduce disability but it would also reduce the huge economic burden associated with hospitalization of the elderly." One in five Americans over the age of 65 suffers from sarcopenia. In 2000 the direct health care cost of treating it were estimated to be more than $18.5 billion. With the number of Americans older than 65 estimated to double by the middle of the century those costs are expected to increase dramatically. Preventing older Americans from being hospitalized is more than just a matter of saving health care dollars, it may also save lives. Numerous studies show that even short stays in the hospital are associated with a greater future risk of functional decline and disability. "Most methods of measuring muscle mass or density rely on complex imaging procedures, such as using quantitative computed tomography (QCT). Those are time consuming and expensive," says Cawthon. "However, we found that much simpler methods - such as measuring walking speed - are much easier and cheaper to do, and are even more accurate in determining a person"s risk of future hospitalization. This gives us the ability to screen larger groups of people and help those at risk with some simple interventions, such as physical exercise." Jennifer Beal Wiley-Blackwell


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