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Chemo Delivered Directly To Ovarian Cancer Cells Using EphA2-Targeted Therapy
With a novel therapeutic delivery system, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovarian cancer cells. Using the EphA2 protein as a molecular homing mechanism, chemotherapy was delivered in a highly selective manner in preclinical models of ovarian cancer, the researchers report in the July 29 issue of the Journal of the National Cancer Institute.
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GTx's Toremifene 80 Mg Increased Bone Mineral Density In Multiple Clinically Relevant Subpopulations Of Prostate Cancer Patients
GTx, Inc. (Nasdaq: GTXI) announced the presentation of data demonstrating that toremifene 80 mg treatment compared to placebo increased bone mineral density (BMD) in multiple clinically relevant subpopulations of men with prostate cancer on androgen deprivation therapy (ADT). The data, an analysis of results of the recent Phase III clinical trial evaluating toremifene 80 mg for the prevention of bone fractures and treatment of other estrogen deficiency side effects of androgen deprivation therapy in men with prostate cancer, were presented yesterday at the 2009 Annual Meeting of the American Society of Clinical Oncology. Purchase zoloft to treat depression.
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Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity
Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli.
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HCL Welcomes Government Proposals For More Flexible NHS, UK

HCL plc, the UK"s largest health and social care recruitment agency, said the Government"s proposals to reform the NHS by devolving power to frontline professionals and patients will mean a greater need for flexible staffing and more collaboration between the public and private sectors. The Government strategy document "Building Britain"s Future", outlines proposals to reduce bureaucracy in the NHS and give patients enforceable rights to high standards of care. The proposals include Personal Health Budgets, faster access to hospital treatment and "clear redress mechanisms" if those entitlements were not met - including the right to request an immediate appointment at another hospital if their local one has no capacity. HCL said that these measures will make it harder for hospital managers to plan patient numbers month on month and thus lead to greater flexible staffing requirements as hospitals need to staff up and staff down quickly to cope with greater patient churn. Kate Bleasdale, Executive Vice Chairman of HCL, said: "We welcome a move away from the top down targets culture to a culture of entitlement that gives more power to frontline professionals. These new proposals pave the way for a more innovative and collaborative partnership between the public and private sectors, particularly in staffing where it is important to maintain the right balance of permanent and flexible healthcare staff to meet the fluctuating needs of the local population. "HCL has close and long-standing relationships with many of the UK"s leading hospitals and we understand that each one"s culture and needs are different. We are committed to working hand in hand with NHS Trusts to ensure that their staffing needs continue to be met, to help them achieve greater efficiency and most importantly ensure faster treatment and better outcomes for patients." HCL plc


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