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Health Care Reform A Priority For People With Arthritis
The Arthritis Foundation supports health care reform, which provides universal and affordable health care for the 46 million Americans living with arthritis.
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American Dental Association, The Forsyth Institute Collaborate To Pilot Evidence-Based Dentistry Training Course
The American Dental Association (ADA) Center for Evidence-Based Dentistry (EBD) and The Forsyth Institute announce the offering of an intensive, five-day training course in evidence-based principles and tools, including systematic reviews and applications for clinical decision making. Drugshop to buy zoloft online and other pills.
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Model For New Generation Of Blood Vessels Challenged
In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.
Diagnostics

Identification Of New Breast Cancer-Promoting Gene

A team of researchers, at the Genome Institute of Singapore, has identified a new gene that seems to contribute to aggressive breast cancer behavior. As discussed in an accompanying commentary, by Gordon Mills and colleagues, the data generated in this study provide new insight into cellular processes underlying tumor cell proliferation and metastasis and identify potential new therapeutic targets. In the study, a new informatics approach was used to analyze microarray expression profiles of primary human breast cancers and the gene RCP was identified as a potential breast cancer-promoting gene. Importantly, this gene is found in a region of the genome frequently amplified in human breast cancer. In vitro analysis indicated that overexpression of RCP protein in normal human breast epithelial cells caused them to acquire tumor cell characteristics and function. Conversely, decreasing expression of RCP protein in human breast cancer cell lines reduced their in vitro tumor cell characteristics and in vivo ability to form tumors and metastasize when transplanted into immunodeficient mice. Further analysis identified some of the molecules affected by RCP overexpression, including the known tumor-promoting protein RAS. These data led the authors to suggest that one mechanism by which RCP promotes breast cancer is likely to be through activation of the RAS signaling pathway and that targeting RCP might provide a way to therapeutically inhibit this known tumor-promoting pathway. TITLE: RCP is a human breast cancer-promoting gene with Ras-activating function https://www.the-jci.org/article.php?id=37622 AUTHOR CONTACT: Lance David Miller Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. Bing Lim Genome Institute of Singapore, Singapore, Singapore. ACCOMPANYING COMMENTARY TITLE: Genomic amplicons target vesicle recycling in breast cancer https://www.the-jci.org/article.php?id=40256 AUTHOR CONTACT: Gordon B. Mills University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Karen Honey Journal of Clinical Investigation


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