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What Are Electrolytes?
An electrolyte is "any compound that, in solution or in molten form, conducts electricity and is decomposed (electrolyzed) by it. It is an ionizable substance in solution" (Medilexicon"s medical dictionary). An electrolyte is any substance that contains free ions that behaves as an electrically conductive medium (conducts electricity). All higher forms of life cannot exist without electrolytes, and that includes humans.
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Clinton Embarks On 7 Nation African Tour
"U.S. Secretary of State Hillary Clinton heads this week on a seven-nation tour of Africa aiming to prove U.S. commitment to the continent after the administration"s early focus elsewhere," AFP/ABS-CBN News reports. According to the news service, "Clinton will seek to build ties with three African powers -- Kenya, Nigeria and South Africa -- and visit three nations recovering from conflict -- Angola, Democratic Republic of Congo [DRC] and Liberia. She will end with a stop in small U.S. ally Cape Verde" (8/3). "Her visit is the earliest in any U.S. administration that both the President and the Secretary of State have visited Africa," VOA News reports (Clottey, 8/2). Purchase zoloft to treat depression.
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Yale Discovery May Open Door To Drug That Cuts Appetite And Boosts Energy
In a major advance in obesity and diabetes research, Yale School of Medicine scientists have found that reducing levels of a key enzyme in the brain decreased appetites and increased energy levels.
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Motor Neuron Differentiation Specified By 2 Signals -- From Within And Out Of Cell

Two signals - an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 - cooperate to activate chromatin (the basic material of chromosomes) and help determine that certain nerve progenitor cells become motor neurons, said researchers from Baylor College of Medicine in a report in the current issue of the journal Neuron. "This finding is important for many reasons. For example, as we understand more about what happens, the more likely we will be able to generate motor neurons from different types of stem cells," said Dr. Soo-Kyung Lee, assistant professor of molecular and human genetics and molecular and cellular biology at BCM. (A motor neuron conducts impulses from the spinal cord to a muscle fiber, controlling movement and other activities.) "It will also be useful as a tool for drug screening, allowing us to determine whether a drug is killing or enhancing the activity of motor neurons." In a delicate series of experiments, she and her colleagues showed that a complex consisting of Neurogenin2 and the retinoic acid receptor, when bound to retinoic acid, recruit a particular enzyme (histone acetyltransferase CBP) to their complex. This causes a chemical reaction called acetylation of the histones (the spools around which DNA winds in the chromatin), stimulating the transcription of the gene into the protein for which it holds the genetic code. "These changes lead to strong expression of the motor neuron genes in nerve progenitor cells, converting them to motor neurons," said Lee. "What is striking is that the retinoic acid receptor uses the Neurogenin2 site to bind to the DNA." In mice that lack CBP, she said, there is marked reduction in motor neurons. The finding could play a role in unraveling the secrets of diseases such as the muscular dystrophies. Notes: This work was spearheaded by Dr. Seunghee Lee. Others who also took part in this study are Drs. Bora Lee and Jae W. Lee, all of BCM. Funding for this work came from the National Institute of Neurological Disorders and Stroke, the PEW Trust, the March of Dimes Foundation and the Intellectual and Developmental Disability Research Centers. Glenna Picton Baylor College of Medicine


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