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Model For New Generation Of Blood Vessels Challenged
In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought. The findings, published today in the journal Nature Medicine, open up a new field for developing treatments.
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What Is A Virus? What Is A Viral Infection?
A virus (from the Latin virus meaning toxin or poison) is a microscopic organism consisting of genetic material (RNA or DNA) surrounded by a protein, lipid (fat), or glycoprotein coat. Viruses are unique organisms because they cannot reproduce without a host cell. After contacting a host cell, a virus will insert genetic material into the host and take over the host"s functions. The cell, now infected, continues to reproduce, but it reproduces more viral protein and genetic material instead of its usual products. It is this process that earns viruses the classification of "parasite". Purchase zoloft to treat depression.
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Researchers Profile Gene Activity In Acutely Ill Idiopathic Pulmonary Fibrosis Patients
New research may help doctors pinpoint when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill. The findings may also point the way to interventions that could sustain the lives of IPF patients until life-saving transplants could be performed.
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News From The June Issue Of CHEST

PULMONARY HYPERTENSION: A CASE OF MISTAKEN IDENTITY? New research shows that patients who are diagnosed with pulmonary arterial hypertension (PAH) but fail to respond to targeted therapies may actually have a condition known as pulmonary veno-occlusive disease (PVOD), a subtype of PAH. Australian researchers reviewed 14 cases of clinically diagnosed PAH who had failed medical therapy and found that 12 patients (86 percent) had PVOD and 2 patients (14 percent) had PAH only. Although there were no significant differences in clinical presentations between patients with PVOD and PAH only, there were considerable differences in the vessel pathologic findings and pathophysiology between the two conditions. Researchers speculate that these differences may be the reason why some patients with PAH do not respond to standard PAH therapy. The researchers conclude that further research is needed to determine if PVOD should be considered an individual type of PAH or remain a PAH subtype. The study is published in the June issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians. OVERCOMING BARRIERS TO PAIN MANAGEMENT IN THE ICU A new article underscores the many complexities and challenges associated with managing pain in the critically ill patient. Although the complex conditions presented by the critically ill patient provide significant obstacles, the authors discuss additional barriers to optimal pain management, including outdated clinical practices and faulty systems. The authors also present a number of structured approaches that have been shown to be successful in improving pain treatment in the critically ill patient, as well as future directions for pain management in the ICU. The article is published in the June issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians. URINALYSIS MAY REVEAL SEVERITY OF BREATHING DISORDER IN CHILDREN New research suggests that the urine concentration of lipid mediators may determine the severity of sleep-disordered breathing (SDB) in children. Cysteinyl leukotrienes (CysLTs), lipid mediators associated with inflammatory conditions such as asthma, have been found in high concentrations in the tonsil tissue of children with SDB. Researchers from Greece speculated that high CysLTs concentrations found in urine also could indicate severity of SDB in children. The team measured morning urine concentrations in 19 children with moderate-to-severe SDB, 29 children with mild SDB, 26 children with primary snoring, and 18 control subjects. Results showed that children with moderate-to-severe SDB had higher CysLTs levels than the other groups. Results also showed that urine levels of CysLTs, tonsillar size, and BMI were significant predictors of obstructive apnea-hypopnea index. The report is published in the June issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians. Jennifer Stawarz American College of Chest Physicians


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