Categories
Cardiovascular
Diagnostics
Endocrinology
Health Insurance
Medical Devices
Mental Health
Nutrition
Oncology
Public Health
Sexual Health
Popular Articles
Stretch Mark Cream

San Francisco Chronicle Profiles U.S. Global AIDS Coordinator
"Dr. Eric Goosby wasted no time starting his new job as the U.S. global AIDS coordinator. He flew from the Bay Area to Geneva hours after his confirmation by the Senate and was sworn in when he landed ò€¦ The ambassador is approaching his post with the urgency of a clinician who has spent more than 25 years fighting the disease," the San Francisco Chronicle writes.
generic viagra online
To Maintain Normal Daily Function, Those With Insomnia Need Increased Brain Activation
According to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, patients suffering from chronic primary insomnia (PIs) have higher levels of brain activation compared to normal sleepers during a working memory test. Drugshop to buy zoloft online and other pills.
News of the day
World Financial Crisis And AIDS Backlash Threaten Lives
On the eve of the G8 Summit in Italy, the International Treatment Preparedness Coalition (ITPC) calls on leaders of the world"s richest countries to announce significant additional funds to ensure that AIDS treatment and prevention programs for millions of men, women and children do not become a casualty of the economic down-turn.
Mental Health

Psychotherapy Of Depression Changes Biological Parameters?

A group of German investigators demonstrated that the early increase in phosphorylated CREB (pCREB) is related to treatment response and does not depend on pharmacological interventions or brain-derived neurotrophic factor (BDNF) plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy. The cyclic adenosine monophosphate response element-binding proteins (CREB) and their interaction with brain-derived neurotrophic factor (BDNF) are essential elements in signal transduction pathways important for cellular resilience and neuroplasticity. They play a decisive role in the concept of altered neuroplasticity in major depression. The Authors of this study have previously demonstrated that the increase in phosphorylated CREB (pCREB) in T lymphocytes is significantly associated with clinical improvement in patients treated with antidepressants. In the present study, they focused on patients treated only with psychotherapy to exclude direct pharmacological actions. In addition to pCREB, they also measured the BDNF plasma levels. pCREB in T lymphocytes was determined by Western blot; the BDNF plasma levels with solid-phase ELISA. Psychopathology was evaluated with the Hamilton Rating Scale for Depression (HAMD). Thirty patients meeting DSM-IV criteria for major depressive episodes (MDE) were recruited into this 6-week study. They received interpersonal psychotherapy (IPT) twice weekly. After 6 weeks of IPT, 17 patients responded (reduction of 50% of baseline HAMD); after 1 week of treatment pCREB increased significantly compared to the nonresponder group. Measurement of the BDNF plasma levels revealed no differences between the responder and nonresponder groups. Furthermore, the correlations between BDNF plasma levels and pCREB were not significant. The early increase in pCREB is related to treatment response and does not depend on pharmacological interventions or BDNF plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy. Psychotherapy and Psychosomatics


Add your comment:
Name:
Site address: http://
Your message:
Enter today\\\\'s date, 2 digits
(spam protection):

© Copyright 2009