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Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression In Rheumatoid Arthritis Models By Selective Inhibition Of The Immunoproteasome
Proteolix, Inc. announced that in an article published in Nature Medicine, Proteolix"s selective immunoproteasome inhibitor PR-957 was shown to block disease progression in mouse models of rheumatoid arthritis in a dose-dependent manner and to completely eliminate visible signs of disease at the highest dose. The anti-inflammatory effect induced by PR-957 was rapid and long-lasting, lowering expression of multiple inflammatory mediators, including TNF-a and IL-6. Disease regression was evident 24 hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept in a model of aggressive arthritis.
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In Patients With Heart Attacks, CYPHER(R) Sirolimus-Eluting Coronary Stent Results Sustained Out To Four Years Compared To Bare Metal Stents
Four-year results of a large, multi-center clinical trial show that earlier results favoring the CYPHER® Sirolimus-eluting Coronary Stent over bare metal stents (BMS) in patients with acute myocardial infarction (heart attack) were maintained in long-term follow-up. In addition, there were no differences in key safety measures between the CYPHER® Stent and BMS. Drugshop to buy zoloft online and other pills.
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Action Needed Now To Stop NHS Wales Becoming Unsafe For Staff And Patients - Says British Medical Association Cymru Wales
Doctors" leaders are warning that unless urgent action is taken to plug the gap in the shortage of middle grade doctors, the NHS in Wales could become unsafe both for staff and patients.
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RCP's Response To Lord Darzi's Report, High Quality Care For All, Our Journey So Far.

Responding to the publication of High Quality Care for All, Our journey so far, Professor Ian Gilmore, President of the Royal College of Physicians, said "We welcome the progress made since the publication of the first report from Lord Darzi, particularly the focus on the quality agenda. The challenge for the NHS is to ensure that the components of the agenda are practical and deliverable ensuring that the laudable aspirations can be transferred from paper into practice, especially in an increasingly cash-strapped environment. The College is delighted to be leading the national pilot project on the accreditation of stroke services. Service accreditation is a highly complex area but we believe it is a logical extension of our existing programme of guidelines and audit that have been for decades setting medical standards and improving services at ward level. We believe that service accreditation will complement the regulatory work of the Healthcare Quality Commission and provide the organisational context for individual medical revalidation. In addition we support Academic Health Science Centres which have the opportunity to be a real force in harnessing leading-edge research into new technologies and treatments for the benefits of patients in any healthcare setting, and they should have a key responsibility in spreading evidence based good practice." Royal College of Physicians


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