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Environmental Factors Instruct Lineage Choice Of Blood Progenitor Cells
The research team led by Dr. Timm Schroeder, stem cell researcher at Helmholtz Zentrum MÃønchen, has developed a new bioimaging method for observing the differentiation of hematopoietic progenitor cells (HPC) at the single-cell level. With this method the researchers were able to prove for the first time that not only cell-intrinsic mechanisms, but also external environmental factors such as growth factors can control HPC lineage choice directly. The findings, published in the current issue of the prestigious journal Science, provide an essential building block for understanding the molecular mechanisms of hematopoiesis and are an important prerequisite for optimizing therapeutic stem cell applications.
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Diabetes: MRI May Help In The Diagnosis, Staging And Treatment
Noninvasive imaging (MRI) may aid physicians in the early diagnosis, staging and treatment of diabetes, according to a study performed at Massachusetts General Hospital and Harvard Medical School in Boston, MA. This is the first study of its kind to apply noninvasive imaging techniques to diabetes research. Purchase zoloft to treat depression.
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Cardium Presents Gene Activated Matrix Technology And Update On Excellarate Clinical Development Program At ASGT Annual Meeting
Cardium Therapeutics (NYSE Amex: CXM) and its subsidiary Tissue Repair Company (TRC) announced a presentation entitled "Phase 2b Study of GAM501 (Ad5PDGF-B/Collagen) in the Treatment of Diabetic Ulcers" at the Late Stage Industry Clinical Trials Symposium at the American Society of Gene Therapy (ASGT) Annual meeting in San Diego, California, on May 27, 2009. Dr. Barbara K. Sosnowski, Cardium"s Vice President of Biologics Development and the Chief Operating Officer of Cardium"s Tissue Repair Company Operating Unit, provided an update on TRC"s Phase 2b MATRIX clinical trial and the new formulation of the Excellarate(TM) product candidate, as well as an overview of the prior clinical study of Excellarate.
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Researchers Discover Possible Therapeutic Target To Slow Parkinson's Disease

University of Medicine and Dentistry of New Jersey (UMDNJ) researchers have discovered a therapeutic target that, when manipulated, may slow the progression of or halt Parkinson"s disease, a debilitating neurodegenerative disorder that affects an estimated one million people in the U.S. A team from the Center for Neurodegenerative and Neuroimmunologic Diseases in the Department of Neurology at the UMDNJ-Robert Wood Johnson Medical School carried out the study. M. Maral Mouradian, M.D., center director and William Dow Lovett Professor of Neurology, was its lead investigator. A paper on their findings, titled "Repression of a-synuclein expression and toxicity by microRNA-7," appears in the July 20 edition of the Proceedings of the National Academy of Sciences (PNAS). In this publication, the investigators report that the small RNA molecule microRNA-7, which is present in neurons, directly represses the expression of a-synuclein, a protein that, in excess, proves deleterious to certain types of brain cells. "Individuals who have multiple copies of the a-synuclein gene come down with Parkinson"s, so inhibitors of a-synuclein expression are attractive therapeutic targets," explained Mouradian. "Our manipulation protects neuronal cells from the toxicity that results from increased levels of this protein." There is no cure for Parkinson"s and there are no neuroprotective treatments as of yet, making this new strategy to manipulate the molecular underpinnings of the disease a significant discovery, Mouradian added. The University of Medicine and Dentistry of New Jersey (UMDNJ) is the nation"s largest free-standing public health sciences university with more than 5,700 students attending the state"s three medical schools, its only dental school, a graduate school of biomedical sciences, a school of health related professions, a school of nursing and a school of public health on five campuses. Annually, there are more than two million patient visits at UMDNJ facilities and faculty practices at campuses in Newark, New Brunswick/Piscataway, Scotch Plains, Camden and Stratford. UMDNJ operates University Hospital, a Level I Trauma Center in Newark, and University Behavioral HealthCare, a statewide mental health and addiction services network. UMDNJ


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