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New Five-Question Test Helps Assess Asthma Control In Children Under Five Years Of Age
Caregivers of children under five years of age can now answer five simple questions to determine if their child"s breathing problems are not under control. AstraZeneca funded a research project to create the Test for Respiratory and Asthma Control in Kids, or TRACK, the first validated respiratory- and asthma-control assessment test specifically for patients under five years of age. TRACK helps evaluate respiratory control based on guidelines -- defined asthma impairment and risk.
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Ambulance Service Makes Progress Against Tougher Response Time Targets
Ambulance Trusts across the country have significantly reduced the time taken to reach patients, according to data published today by the NHS Information Centre. 74.3% of the most urgent calls (Category A) were responded to in less than 8 minutes from a call being received. Drugshop to buy zoloft online and other pills.
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Scientists Shed New Light On Cause Of Inherited Movement Disorder
University of Utah School of Medicine researchers and their colleagues at University of Texas (UT) Southwestern Medical Center have found strong evidence that abnormal calcium signaling in neurons may play an important role in the development of spinocerebellar ataxia type 2 (SCA2), a disorder causing progressive loss of coordination, speech difficulty, and abnormal eye movements. Their findings are published in the July 27, 2009 issue of Journal of Neuroscience.
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Sleep And Weight Gain: A Molecular Link

There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity. Previous studies have shown that mice lacking the CaV3.1 T-type calcium channel have disrupted sleep/wake activity. In this study, the researchers found that these mice were resistant to weight gain when fed a high-fat diet. Consistent with these data, when normal-weight rodents were administered a drug that specifically antagonized T-type calcium channels during their inactive phase they showed increased sleep and were protected from weight gain due to a high-fat diet. Further, when the same drug was given to obese rodents it reduced body weight and fat mass. The authors conclude that the benefits of the drug are likely to be a result of better alignment of feeding patterns and the circadian rhythm, and that targeting T-type calcium channels might provide a new avenue of research for those developing drugs to treat obesity. TITLE: Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice AUTHOR CONTACT: Victor N. Uebele Merck Research Laboratories, West Point, Pennsylvania, USA. View the PDF of this article at: https://www.the-jci.org/article.php?id=36954 Karen Honey Journal of Clinical Investigation


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