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Access Pharmaceuticals Announces Publication Of Thiarabine Combination Data
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), announced that new Thiarabine preclinical efficacy data will shortly be published demonstrating that thiarabine combined with clofarabine provides much greater antitumor activity than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their tumors. The publication which will appear in the journal "Cancer Chemotherapy and Pharmacology," was based on work conducted by Access" collaborators at the Southern Research Institute. The paper is entitled "Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine" (thiarabine).
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Hitting Cancer Where It Hurts
Two studies in the May 29th issue of Cell, a Cell Press publication, have taken advantage of new technological advances to search for and find previously unknown weaknesses in a hard to treat form of cancer. The discoveries lend new hope in the fight again tumors that are today considered "undruggable." Purchase zoloft to treat depression.
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Blogs Comment On Planned Parenthood Ad Campaign, Sex-Selective Abortion, Other Topics
The following summarizes selected women"s health-related blog entries.~ "A Radical Notion: Women"s Health Care as Mainstream," Cecile Richards, Huffington Post blogs: "To hammer ... home" the message that "Planned Parenthood and other essential community providers are the affordable, local access to basic preventive care that saves lives," the Planned Parenthood Action Center has introduced advertisements "educating the policy folks involved in fixing our health care system" about "why women"s health care needs to be taken care of in this mega-reform effort," Richards writes. She writes, "From cancer screenings to contraception to immunizations, the majority of women who go to women"s health care centers consider them their primary health care provider," adding, "In fact, more than 90% of what Planned Parenthood health centers do is preventive and primary care." According to Richards, "Essential community providers, including those who provide women"s health care, need to be part of any newly established health care system." She adds that "the three million patients who came to Planned Parenthood health centers last year can testify to it." Richards writes that "[f]amily planning and reproductive health care are unfortunately still not fully part of mainstream health care, even though 98% of women use contraception at some point in their lives -- there"s nothing more universal!" The "fact that women reproduce and, therefore, have different types of health care needs makes some folks on Capitol Hill go pale and start to sweat," Richards writes. She concludes, "Maybe one day we won"t need a special campaign to support women"s health," but "until then, Planned Parenthood is here to make sure women aren"t worse off after health care reform than before" (Richards, Huffington Post blogs, 6/18).~ "The Role of Medical Education in Preserving Abortion Access," Our Bodies, Our Blog: In response to a recent Salon opinion piece that examined whether there will be a next generation of abortion providers, the blog post discusses a few organizations that are "working to increase access to (accurate) abortion-related training." The blog includes links to Medical Students for Choice -- a group that "does student organizing and advocacy to influence medical school curricula, workshops ... and lectures on abortion techniques" -- and The Ryan Program -- which offers "funding, technical expertise, curriculum, workshops and other res to support training opportunities in abortion and contraception for ob-gyn residents." The blog entry also highlights the work of Physicians for Reproductive Choice and Health, which partners with members of the American Medical Student Association "to provide "project in a box" materials for medical students wanting to access and influence their schools" curricula on sexual and reproductive health" (Our Bodies, Our Blog, 6/18). ~ "Regulating Abortion May Be OK But Not To Avoid Sex-Selection," Marianne Mollmann, Huffington Post blogs: "Sex-selective abortion raises a multitude of overlapping ethical concerns regarding eugenics, population control and provider privilege or knowledge," according to Mollmann, advocacy director for the Human Rights Watch"s Women"s Rights Division. Mollmann writes that recent media reports indicating that sex-selective abortion occurs among some ethnic communities in the U.S. "has generated new discussion about what to do -- indeed what to think -- about the practice here." She continues that the "effect of abortion regulations depends on the context and motivation," adding that "[f]rom a human rights perspective, the regulation of medical procedures and interventions is legitimate and indeed often necessary so long as they are based on full respect for the full range of human rights." It is "perhaps tempting to hope that banning sex-selective abortions would safeguard the gender balance of future generations," but the "criminalization of abortion for whatever reason has in the past led only to underground and unsafe prac
Public Health

What Is Dyspraxia? How Is Dyspraxia Treated?

A person with dyspraxia has problems with movement and coordination. It is also known as "motor learning disability". Somebody with dyspraxia finds it hard to carry out smooth and coordinated movements. Dyspraxia often comes with language problems, and sometimes a degree of difficulty with perception and thought. Dyspraxia does not affect a person"s intelligence, but it can cause learning difficulties, especially for children. Dyspraxia is also known as Developmental Co-ordination Disorder (DCD), Perceptuo-Motor Dysfunction, and Motor Learning Difficulties. The terms Clumsy Child Syndrome or Minimal Brain Damage are no longer used. Developmental dyspraxia is an immaturity of the organization of movement. The brain does not process information in a way that allows for a full transmission of neural messages. A person with dyspraxia finds it hard to plan what to do, and how to do it. Experts say that about 10% of people have some degree of dyspraxia, while approximately 2% have it severely. Four out of every 5 children with evident dyspraxia are boys. If the average classroom has 30 children, there is probably one child with dyspraxia in almost each classroom. A study carried out by researchers at Orebro University Hospital, Sweden, indicated that poor physical coordination during childhood is linked to a higher risk of obesity later in life. The English medical word dyspraxia comes from: *The Greek word duspraxia, which means "dyspraxia". *The Greek word duspraxia comes from the Greek word Praxis, meaning "to practice; (concretely) an act; by extension, a function". *The Greek word Praxis comes from an older Greek word Prassein (prattein), meaning ""to pass through, experience, practice". What are the signs and symptoms of dyspraxia? Very early childhood The child may take longer than other children to: *Sit *Crawl (some never go through crawling stage) *Walk *Speak *Stand *Become potty trained (get out of diapers/nappies) *Build up vocabulary *Speak in a clear and articulate way. Many parents of very young children with dyspraxia say they cannot understand what they are trying to say a lot of the time Early childhood Later on the following difficulties may become apparent: *Problems performing subtle movements, such as tying shoelaces, doing up buttons and zips, using cutlery, handwriting. *Many will have difficulties getting dressed. *Problems carrying out playground movements, such as jumping, playing hopscotch, catching a ball, kicking a ball, hopping, and skipping. *Problems with classroom movements, such as using scissors, coloring, drawing, playing jig-saw games. *Problems processing thoughts. *Difficulties with concentration. Children with dyspraxia commonly find it hard to focus on one thing for long. *The child finds it harder than other kids to join in playground games. *The child will fidget more than other children. *Some find it hard to go up and down stairs. *A higher tendency to bump into things, to fall over, and to drop things. *Difficulty in learning new skills - while other children may do this automatically, a child with dyspraxia takes longer. Encouragement and practice help enormously. *Writing stories can be much more challenging for a child with dyspraxia, as can copying from a blackboard. The following are also common at pre-school age: *Finds it hard to keep friends *Behavior when in the company of others may seem unusual *Hesitates in most actions, seems slow *Does not hold a pencil with a good grip *Such concepts as in, out, in front of are hard to handle automatically Later on in Childhood *Many of the challenges listed above do not improve, or do so very slightly *Tries to avoid sports and PE *Learns well on a one-on-one basis, but nowhere near as well in class with other kids around *Reacts to all stimuli equally (not filtering out irrelevant stimuli automatically) *Mathematics and writing are difficult *Spends a long time getting writing done *Does not follow instructions *Does not remember instructions *Is badly organized What causes dyspraxia? Scientists do not know what causes it. Experts believe the person"s nerve cells that control muscles (motor neurons) are not developing correctly. If motor neurons cannot form proper connections, for whatever reasons, the brain will take much longer to process data. In some cases dyspraxia can be inherited (Ref: Great Ormond Street Hospital, England). One study carried out at Children"s Hospital Boston, USA, found that when there was injury to the cerebrum among premature babies; the cerebellum failed to grow to a normal size. The cerebellum grows rapidly late in gestation - much faster than the cerebral hemispheres - premature birth arrests this surge in development. Premature babies with cerebellum problems are likely to have deficits that extend beyond motor, and may benefit from early intervention. A study by scientists at the Universite Laval, Canada found that mothers who take omega-3 during the last months of pregnancy will boost their child"s motor and cognitive development. A study carried out at Johns Hopkins Bloomberg School of Public Health found that fetal heart rates give clues to children"s later development during toddler years. If a person develops dyspraxia later in life it is usually due to traumas suffered by the brain after a stroke, accident or illness. If a person is born with dyspraxia, it is also known as Developmental Dyspraxia. Unfortunately, for many sufferers, there is no obvious cause. How is dyspraxia diagnosed? A diagnosis of dyspraxia can be made by a clinical psychologist, an educational psychologist, a pediatrician, or an occupational therapist. Any parent who suspects their child may have dyspraxia should see their GP (general practitioner, primary care physician), or a special needs coordinator first. When carrying out an assessment, details will be required regarding the child"s developmental history, intellectual ability, and gross and fine motor skills: *Gross motor skills - this refers to how well the child uses his/her large muscles that coordinate body movement. This includes jumping, throwing, walking, running, and maintaining balance. *Fine motor skills - this refers to how well the child can use his/her smaller muscles. Activities which require fine motor skills include tying shoelaces, doing up buttons, cutting out shapes with a pair of scissors, and writing. The assessor will need to know when and how developmental milestones, such as walking, crawling, speaking were reached. The child will be screened for balance, touch sensitivity, and variations on walking activities. If the assessor, or GP, does not have the necessary training, dyspraxia could be missed altogether and the child will not be referred to a specialist. Training on identifying dyspraxia can be patchy, depending on which part of the world you live in, and also which part of specific countries. The same applies to teachers - in some places they are well trained at identifying potential dyspraxia among their pupils, while in others they are not. A new coordination and handwriting test that identifies Developmental Coordination Disorder may identify teenagers who need extra help at secondary school and college. What is the treatment for dyspraxia? Although dyspraxia is not curable, with time the child can improve. However, the earlier a child is diagnosed, the better and faster his/her improvement will be. The following specialists most commonly help people with dyspraxia: *Occupational therapy An occupational therapist will first observe how the child manages with everyday functions both at home and at school. He/she will then help the child develop skills specific to activities which may be troublesome. *Speech and language therapy The speech and language therapist will first carry out an assessment of the child"s speech, and then help him/her communicate more effectively. *Perceptual motor training This involves improving the child"s language, visual, movement, and auditory skills. A series of tasks, which gradually becoming more advanced, are set - the aim is to challenge the child so that he/she improves, but not so much that it becomes frustrating or stressful. Scientists from the University of Leeds, England, developed a set of practical guidelines for use by teachers, childcare professionals and parents that will help pre-school children with co-ordination difficulties, to improve their dexterity. A study carried out by Robert Sekuler, a neuroscientist at Brandeis" Volen Center for Complex Systems, and team, indicates that "What makes one person clumsy and the next person a prima ballerina is a combination of talent and practice" (article not about dyspraxia, but it is interesting). Active Play Experts say that active play - any play that involves physical activity - which can be outdoors or inside the home, gets the motor activity going in children. Play is a way children learn about the environment and about themselves, and particularly for children aged 3 to 5; it is a crucial part of their learning. Active play is where a very young child"s physical and emotional learning, their development of language, their special awareness, the development of what their senses are, all come together. The more children are involved in active play, the better they will become at interacting with other children successfully. Parents, uncles and aunts, and other adults can also become involved with a child"s active play - however, sometimes they should take a step back and let the children really explore so they can try out their own understanding of the world. The risk of negative things happening to children if they play outside are far smaller than the risks of negative things happening to them if they don"t, such as obesity, poor socialization with other children, and having less fun. It is only by taking risks that children learn the importance of,

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