Medical Devices
Evidence suggests that outcomes in many clinical settings leave a lot to be desired, which means that research into quality improvement (QI) in clinical care has the potential to greatly improve the lot of patients. Now a study in the journal Medical Care Research and Review published by SAGE suggests that both theoretical and practical improvements in QI effectiveness studies could make these into much more powerful tools for positive change.
Bosentan appears to be a more cost-effective initial treatment option for patients with moderate pulmonary arterial hypertension (PAH), classified as WHO functional class III, than no active intervention.
The American Psychiatric Association (APA) commended
Some Senators "struggled" Wednesday with the possibility that the health reform overhaul could derail America"s tradition of employer insurance plans, The New York Times reports.
AdvanDx announced it received FDA 510(k) clearance for GBS PNA FISH® for detection of Streptococcus agalactiae, aka Group B Strep, from turbid Lim Broths inoculated with vaginal and rectal swabs obtained from pregnant women between 35 and 37 weeks gestation. The 90 minute molecular diagnostic test enables rapid and highly sensitive detection of Group B Strep from Lim Broths to help detect colonization in pregnant women.
"Dr. Eric Goosby wasted no time starting his new job as the U.S. global AIDS coordinator. He flew from the Bay Area to Geneva hours after his confirmation by the Senate and was sworn in when he landed ò€¦ The ambassador is approaching his post with the urgency of a clinician who has spent more than 25 years fighting the disease," the San Francisco Chronicle writes.
Ohio students who participate in the Cleveland Metropolitan School District"s comprehensive sex education program show more knowledge and better attitudes toward safer-sex practices than students who do not participate, according to a study released Tuesday by Philliber Research Associates, the AP/Dayton Daily News reports. The school district uses a graduated sex education program for students in kindergarten through 12th grade. The program begins with instruction about the human body and inappropriate touching and progresses to discussions about sexually transmitted infections and relationships. The study, which was funded by the AIDS Funding Collaborative in Cleveland, found that more than 75% of parents of children in kindergarten through sixth grade approved of the program.The Collaborative for Comprehensive School Age Health, a coalition of northeast Ohio organizations that opposes abstinence-only sex education, said that the report validates the effectiveness of the city"s program. The study"s release coincides with advocates" efforts against two other sex education-related measures under consideration in the state budget plan. According to the AP/Daily News, the Republican-controlled state Senate wants to require the state Department of Education to apply for federal abstinence-only education funding. The state Senate also wants Ohio to continue to require legislative approval before any changes can be made in health education, although Gov. Ted Strickland (D) and the Democrat-controlled House want to change these requirements, the AP/Daily News reports (AP/Dayton Daily News, 6/23).
Britain"s workplace safety regulator today warned businesses in the North East of the continued need to put safety first as new figures reveal the number of employees killed at work.
Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage. In our previous work, p90RSK is observed significantly up-regulated in association with elevated collagen type I levels in rat liver fibrosis. But detail mechanism of this phenomenon is still unknown.
For years, proponents have touted the benefits of embryonic stem cell research, but the potential therapies still face hurdles. Side effects such as tumor development, a lack of an effective and long-term animal model to test new therapies, and genetic incompatibility between the host and donor cells are some of the problems faced by researchers. Now, scientists at the University of Missouri have developed the ability to take regular cells from a pig"s connective tissues, known as fibroblasts, and transform them into stem cells, eliminating several of these hurdles. The new study appeared in a recent issue of the Proceedings of the National Academy of Sciences (PNAS).
The American Diabetes Association, the nation"s leading health organization in the fight to stop diabetes, is pleased to announce that the National Employment Lawyers Association has honored Gary Branham, who successfully fought discrimination based on diabetes, as one of three "Workplace Heroes & Heroines." The award honors those who have made a difference in the evolution of employee rights, and advancing equality and justice in the American workplace during the past twenty years. (For more information on this award, see http://www.nela.org.)
Veritide Ltd., a developer of innovative biological identification and detection solutions, today reported that new independent data to be presented at the Biodetection Technologies 2009 conference confirm the exceptional accuracy of its Ceeker™ (pronounced "seeker") portable bacterial detection device in discriminating between anthrax spores and similar-looking hoax substances. The data show that in over two weeks of testing at the Midwest Research Institute in Florida, the company"s Ceeker scanner accurately identified 100% of the anthrax samples used and was correct in 95% of tests involving hoax substances. These test results are consistent with similar results produced last year by a New Zealand forensic testing agency, Environmental Science and Research (ESR).
In a review in Science, a University of Rochester Medical Center researcher sorts out the controversy and promise around a dangerous subtype of cancer cells, known as cancer stem cells, which seem capable of resisting many modern treatments.
The new 4th generation rapid HIV diagnostic test - Determine® HIV 1/2 Ag/Ab Combo - from Inverness Medical is capable of detecting HIV infection several days earlier than HIV antibody only tests and is ideal to help diagnose and screen for early HIV infection. The ability of this test to enhance the diagnosis of those with acute HIV infection will provide additional benefits in HIV prevention programs and ultimately contribute to a reduction in the spread of HIV. Inverness Medical will be showcasing the new Determine Combo test at the International AIDS Society Conference 2009 in Capetown, South Africa, 19-22 July on stand #203.
-- 9 confirmed cases in Wales, including one new case:
Newly appointed IHS Director Yvette Roubideaux on Friday announced that American Indian tribes will receive $500 million as part of the $787 billion economic stimulus package to fund health care projects, the Green Bay Press-Gazette reports. According to the Press-Gazette, American Indian tribes frequently cite lack of adequate health care as a major issue on reservations. President Obama also included a $454 million increase for IHS programs in his 2010 budget proposal to address such barriers.The $500 million includes:
A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) which could lead to 30 per cent more proteins being available as potential targets for drug development opening up exciting possibilities in drug discovery.
Women who have depression symptoms prior to becoming pregnant are at an increased risk for having preterm births, with the risk twice as high for black women as for white women, according to a study in the Journal of Women"s Health, Reuters reports. For the study, Amelia Gavin of the University of Washington and colleagues examined the links between race, preterm birth and pre-pregnancy depressive mood among 555 women. The study used data collected from 1990-1996 as part of a larger, long-term investigation of heart disease risk.Researchers determined that 18.1% of the 249 black women in the study gave birth prior to 37 weeks" gestation, compared with 8.5% of the 306 white women in the study. The study also found that 9.4% of black women had pre-pregnancy symptoms of depressive mood, compared with 7.2% of white women. After researchers accounted for other factors associated with preterm birth, such as body weight and sociodemographic characteristics, black women"s risk remained more than twice that of white women.Gavin said, "The black-white disparity in preterm birth may be in part a consequence of different exposures to depressive mood prior to pregnancy." She said, "Reproductive outcomes must be viewed in light of women"s health over the entire life-course, as well as during pregnancy," adding that the study"s results suggest that "the experience of cumulative health disadvantages or "weathering"" might play a role in increased risk for preterm birth (Hendry, Reuters, 6/25).
In Ohio, a nursing home coalition warns of "life-threatening health risks" if Medicaid reimbursements are cut under Gov. Ted Strickland"s proposed budget plan while diabetes patients in the state are threatened by a lack of coverage.
Kenya"s Medical Services Permanent Secretary James Ole Kiyiapi announced Thursday that the government is in negotiations with PEPFAR for support in building additional blood transfusion centers in the country, Capital News reports. In an opening address at the 5th International Africa Society for Blood Transfusion, Ole Kiyiapi said the government estimates it will cost about Sh230 million ($2.99 million) to build the new centers and train appropriate staff.
July 1, 2009
Staphylococcus epidermidis is quite an opportunist. Commonly found on human skin, the bacteria pose little danger. But S. epidermidis is a leading cause of infections in hospitals. From catheters to prosthetics, the bacteria are known to hitch a ride on a range of medical devices implanted into patients.
Transferring heart attack patients to specialized hospitals to undergo angioplasty within six hours after receiving clot-busting drugs reduces the risk of life-threatening complications, according to a Canadian-led study published today. The findings, published in the New England Journal of Medicine, suggest that routine early transfer of patients after clot-busting drugs are administered results in significantly better outcomes than the current practice of transferring patients only when the clot-busting drugs fail.
Researchers at UC Davis have developed a new test that will measure the protein deficit responsible for fragile X syndrome - the single-most common cause of intellectual impairment and the most-commonly inherited cause of autism. The test, described in a study appearing online in the July 2009 issue of The Journal of Molecular Diagnostics, is the first to measure an individual"s level of the fragile X mental retardation 1 (FMR1) protein.
A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme. The finding, reported in the July 1 issue of Clinical Cancer Research, paves the way for a Phase 1 clinical trial expected to begin in late 2009.
AIDS Vaccine Day, May 18, marks the occasion in 1997 when U.S. President Bill Clinton challenged researchers to come up with an AIDS vaccine within the following decade, stating that such a vaccine was the only way to eliminate the threat of AIDS. Twelve years later, the goal of an effective HIV vaccine remains unfulfilled, but the need for one remains urgent. AIDS is the number four killer in the world and number one in sub-Saharan Africa. Despite education and prevention campaigns, every day 7,500 people become infected with HIV. Antiretroviral drugs can prolong the lives of those who are infected, but they are not cures, and because of their cost and logistical difficulties, they reach only a minority of those who need them. And for every two individuals who go on antiretroviral treatment, five become HIV infected. As with any major viral pandemic, a vaccine remains the best hope of ending, and not just mitigating, AIDS.
When a patient is diagnosed with metastatic disease the primary site of the cancer is usually, but not always, evident. When the origin of the cancer is not identified it is described as a Cancer of Unknown Primary site, or CUP.
Doctors will have greater clarity around releasing a patient"s full medical notes to insurance companies after the Privacy Commissioner concluded that the law allows insurers to collect only the information that they need to make insurance decisions.
Diabetes patients who are hospitalized for non-critical illnesses, and develop hypoglycemia while hospitalized, are likely to remain hospitalized longer and face greater risk of mortality both during and after hospitalization, according to a study published in the July issue of Diabetes Care.
Because tobacco use impairs military readiness, harms the health of soldiers and veterans, and imposes a substantial financial burden on the departments of Defense and Veterans Affairs, these agencies should implement a comprehensive strategy to achieve the Defense Department"s stated goal of a tobacco-free military, says a new report from the Institute of Medicine. DOD should gradually phase in a ban on tobacco use in the military, starting at military academies and officer training programs and among new recruits, the report says. DOD should also stop selling tobacco products in Army and Air Force commissaries -- Navy and Marine Corps commissaries already do not sell them -- and should stop selling them at a discount in military exchanges and other stores. In addition, Congress should allow VA to establish tobacco-free medical centers.
Experimental devices that read brain signals have helped paralyzed people use computers and may let amputees control bionic limbs. But existing devices use tiny electrodes that poke into the brain. Now, a University of Utah study shows that brain signals controlling arm movements can be detected accurately using new microelectrodes that sit on the brain but don"t penetrate it.
The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute to endothelial dysfunction and increased intrahepatic resistance.
Medtronic, Inc. announced that DFine Europe GmbH has accepted the terms of a preliminary injunction granted to Medtronic GmbH by a German Competition Court. The preliminary injunction stops DFine Europe GmbH from using certain misleading marketing claims related to Medtronic"s Kyphon® Balloon Kyphoplasty products in Germany.
Deterioration of renal function with CNI therapy has been widely reported in liver transplant recipients. Microproteinuria has been used to monitor the early changes of nephropathy in renal disease or cardiovascular events. However, whether microproteinuria could be used as an early and sensitive indicator to monitor CNI-related nephrotoxicity in liver transplant recipients has not been unequivocally addressed.
Patients who have regained weight after gastric bypass surgery now have access to an incisionless procedure that appears highly effective at reversing weight gain, according to data presented at the annual meeting of the American Society of Metabolic and Bariatric Surgeons. Santiago Horgan, MD, professor of surgery and director of the Center for the Treatment of Obesity at UC San Diego, presented six-month outcomes from a national registry of 116 patients who underwent the procedure, known as ROSE (Restorative Obesity Surgery, Endolumenal).
Pig heart valves used to replace defective aortic valves in human patients failed much earlier and more often than expected, says a report from cardiac surgeons at Washington University School of Medicine in St. Louis. This is the first report to demonstrate this potential problem, the researchers say.
UT Southwestern Medical Center researchers are conducting two pilot clinical trials to determine whether a single, early dose of estrogen can improve survival and neurological outcomes after severe traumatic brain injury or traumatic hemorrhagic shock.
Analysis of the longest running ICSI programme in the United States has found reassuring evidence that babies born from frozen embryos fertilised via ICSI (intracytoplasmic sperm injection) do just as well as those born from frozen embryos fertilised via standard IVF treatment.
Medtronic, Inc. (NYSE:MDT) announced completion of enrollment in the TTOP-AF (Tailored Treatment of Permanent Atrial Fibrillation) clinical trial. The study is evaluating the use of the latest radiofrequency (RF) ablation technology, the Medtronic Ablation Frontiers Cardiac Ablation System, for the treatment of continuous atrial fibrillation (AF). A leading advancement from currently available RF ablation tools, the system is comprised of a RF generator (or energy ) and three anatomically shaped mapping and ablation catheters that target three areas of the heart for AF treatment. The system is approved for use in Europe and is under investigational use in the United States.
New data show that at 24 months, patients in the chronic phase of Philadelphia chromosome positive (Ph+) chronic myeloid leukaemia (CML) who are intolerant or resistant to current first-line therapy (Glivec) experienced a rapid response and significant reduction in leukaemia burden when treated with 400mg Tasigna twice-daily1. Furthermore, the research shows that the majority of patients in both the chronic and accelerated phases of the disease are still alive at 2 years when treated with Tasigna1,2.
Roll Call reports that "several major industry stakeholders" will be "noticeably absent from the advertising airwaves over the July Fourth recess. Though they will continue to keep in touch with Members through meetings and grass roots, AARP, the American Medical Association, America"s Health Insurance Plans, the Federation of American Hospitals and AdvaMed all say they are sitting out this recess when it comes to advertising campaigns." Senate Finance Chairman Max Baucus, D-Mont., and White House aides have "warned that any groups that run ads attacking reform efforts before the bills have been crafted would lose their seats at the bargaining table," but the "advocacy ad floodgates" may "open shortly." Until then, "groups are working in a lower-profile way to get their messages across to Members," such as planning in-district meetings with Members and activating grassroots networks.
A long-term care program could produce some needed dollars, at least in the short range, CQ Politics reports: "A new insurance program for long-term care that Democrats have included in a Senate health overhaul bill would produce about $58 billion in revenue for the government over the next 10 years, according to the Congressional Budget Office, helping to offset the cost of the legislation. Democrats acknowledge that spending in the long-term care program would increase after 10 years and that it likely would not remain a very profitable enterprise for the government. It is even possible, they say, that the program could become insolvent; in that case, the secretary of Health and Human Services would be authorized to close its enrollment. "The CBO says that premiums would have to rise significantly higher than Democrats have assumed for the program to remain financially sound."
A survey by The Royal College of Radiologists (RCR) has confirmed that there are marked
HIV rates have been steadily increasing over the last three years in Salt Lake County, which includes Salt Lake City and surrounding areas, according to the Salt Lake Valley Health Department, the Deseret News reports. Health officials contend that lack of awareness of HIV, personal concern about becoming infected and sexual health discussions - especially among young adults - are driving the increase. Preliminary data indicate that the trend will continue in 2009, according to health officials. Stan Penfold, the executive director of the Utah AIDS Foundation, said, "Rates grow because there is a lack of conversation around HIV and what the risk factors are. It is really easy to compartmentalize because of the stigma associated with HIV, but the average age of infection is getting younger and younger," he said. Lynn Beltran, STD and HIV program manager for the Salt Lake County Health Department, noted that sex education in high schools also is a concern, but added, "Everyone needs to educate themselves and understand how to make healthy decisions about sex" (Norlen, Deseret News, 6/28).
New research from the US adds to mounting evidence that when diagnosing bipolar disorder in children doctors and clinicians should consider
Mental health services could be improved by
Accredited Practising Dietitian and PhD student Janice Sangster has been awarded the Dietitians
The recent release of two large randomized trials suggests that if there is a benefit of screening, it is, at best, small, says a new report in CA: A Cancer Journal for Clinicians. Authored by Otis W. Brawley, M.D. of the American Cancer Society and Donna Ankerst, Ph.D. and Ian M. Thompson, M.D. of the University of Texas Health Science Center at San Antonio, the review says because prostate cancer is virtually ubiquitous in men as they age, it is clear that a goal of "finding more cancers" is not acceptable. Instead, public health principles demand that screening must reduce the risk of death from prostate cancer, reduce the suffering from prostate cancer, or reduce health care costs when compared with a non-screening scenario. The authors suggest prostate cancer screening has yet to reach one of these standards to date.
Responding to the publication of High Quality Care for All, Our journey so far, Professor Ian Gilmore, President of the Royal College of Physicians, said
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria. In the June 29, 2009 issue of the Journal of Cell Biology, Matthew McConnell, Matthew Tyska, and colleagues now find that microvilli extend their functional reach even further using a molecular motor to send vesicles packed with gut enzymes out into the lumen to get a head start on breaking down their substrates.
Scientists discover novel mechanism that increases the risk of common colorectal cancer
The UK spends around ÷£2.5 billion each year on dental materials to replace or strengthen teeth*. The Chewing Robot is a new biologically inspired way to test dental materials and it will be shown to the public for the first time at this year"s Royal Society Summer Science Exhibition [30 June to 4 July].
Varian Medical Systems, Inc., (NYSE: VAR) announced it has acquired the assets of Houston-based IKOEmed and IKOEtech, privately-owned suppliers of software used in the planning of radiotherapy and radiosurgery treatments. The acquisition enables Varian to offer hospitals and clinics an additional software tool to automate and accelerate the most time-consuming portion of the treatment planning process. Varian is paying approximately $2.2 million plus an additional amount based on achievement of specified milestones to acquire the IKOE assets.
Ablynx [Euronext Brussels: ABLX], a pioneer in the discovery and development of Nanobodies®, a novel class of antibody-derived therapeutic proteins, announced that it has advanced ALX-0061, a new Nanobody®-based therapeutic programme, into preclinical development for the treatment of autoimmune and inflammatory diseases.
There is no way to know how the newest strain of the H1N1 influenza virus will behave in the future. But scientists, notably those working at the intersections of epidemiology, mathematics, modeling and statistics, are monitoring it closely to identify anomalies on its pattern of spread while evaluating ways of mitigating its impact.
New data from an economic analysis presented today at this year"s European Society of Human Reproduction and Embryology (ESHRE) congress showed that, within the parameters of the simulation model used, the in vitro fertilisation (IVF) treatment MENOPUR (highly-purified human menopausal gonatropin or HP-hMG) offered considerable cost-savings over recombinant follicle stimulating hormone (rFSH).1 The cost-effectiveness of HP-hMG compared with rFSH suggested by this data could make it a more attractive choice for use in infertility treatment within a fixed healthcare budget.
Doctors at the Cedars-Sinai Heart Institute announced today the completion of the first procedure in which a patient"s own heart tissue was used to grow specialized heart stem cells that were then injected back into the patient"s heart in an effort to repair and re-grow healthy muscle in a heart that had been injured by a heart attack. The minimally-invasive procedure was completed on the first patient on Friday, June 26.
Amira Pharmaceuticals, Inc. announced initial positive data from a Phase 1 clinical study of AM211, the company"s oral selective antagonist of the DP2 (also known as CRTH2) receptor.
Upsher-Smith Laboratories, Inc. presented the results of a secondary analysis to determine the response rates to three doses of transdermal Divigel(R) (estradiol gel) 0.1 percent at the recent 57th Annual Clinical Meeting of the American College of Obstetricians and Gynecologists (ACOG) in Chicago. The objectives of this secondary analysis of a phase III efficacy trial were to determine the percent of postmenopausal women who achieved a greater than 50 percent reduction in the frequency of moderate to severe vasomotor symptoms (MSVMS), or hot flashes, and to assess the change from baseline in a quality of life (Kupperman) index score that evaluated various menopausal symptoms. Divigel(R) doses studied included 1.0 mg, 0.5 mg and 0.25 mg of estradiol/day - the lowest effective approved dose of estradiol available for the treatment of MSVMS. The analysis showed a significantly greater percentage of women in all treatment groups versus placebo experienced > / = 50 percent reduction in the frequency of MSVMS at week 12. In the Divigel(R) 1.0 mg estradiol/day dosing group, 90 percent of women reported at least a 50 percent reduction in the frequency of MSVMS. Additionally, at 12 weeks, each of the doses of Divigel(R) significantly reduced the severity of menopausal symptoms identified by a quality of life index score compared to placebo.
Lung Cancer Alliance (LCA) released its updated 2009 Facts About Lung Cancer illustrating again the devastating toll caused by lung cancer. LCA last released its Fact Sheet in 2008.
The General Optical Council (GOC) is today reminding all optical businesses, students and supervisors to ensure their current arrangements for professional supervision of students meet the requirements outlined by the GOC, and examination or assessment bodies. This follows the recent Fitness to Practise (FTP) hearing involving Boots Opticians Ltd (a GOC-registered business); Trevor Burgess, a registered student dispensing optician; and Richard Simmons, a registered dispensing optician.
Somerset Partnership NHS Foundation Trust has announced the appointment of a new Non Executive Director to its Board.
A 12-year study that followed over 60,000 Britons, half of whom were vegetarian, suggests that vegetarians had a lower risk of developing
Senate Democrats and Obama administration officials hoping that preventive care would create federal savings have been disappointed to learn that it does not create expected cost savings.
Responding to the publication of Lord Darzi"s report, High Quality Care for All: Our Journey So Far, Dr Peter Carter, Chief Executive & General Secretary of the Royal College of Nursing (RCN), said:
EFPIA, the voice of the pharmaceutical industry in Europe, announces an important step in its efforts to protect Europe"s citizens against counterfeit medicines. EFPIA has agreed to run a pilot of its coding and identification solution in Sweden later this year in partnership with Swedish retail pharmacy chain Apoteket AB and local wholesalers Tamro and KD.
People with ankle injuries who do not respond successfully to initial treatment may have a second chance at recovery, thanks to two new procedures developed to restore the injured area, according to a study published in the July 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS).
MUSCLE BIOLOGY: Not strong enough: the protein OPN promotes muscle degeneration
With the increasing popularity of whitening one"s teeth, researchers at the Eastman Institute for Oral Health, part of the University of Rochester Medical Center, set out to learn if there are negative effects on the tooth from using whitening products.
Medical scientists from Southampton have contributed to a major new report published today, setting out plans to enhance the nation"s health by improving diet, increasing physical activity and cutting harmful drinking.
Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbr̿ck Center for Molecular Medicine (MDC) Berlin-Buch and Charit̩ - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases. In the future, their findings may help identify patients with aggressive tumors at an earlier stage (Gastroenterology 2009, doi:10.1053/j.gastro.2009.03.041).*
Schering-Plough Corp., (NYSE: SGP) announced results from the Phase III ENGAGE clinical trial demonstrating that a single injection of corifollitropin alfa, first in the class of sustained follicle stimulants, achieved similar efficacy to recombinant follicle stimulating hormone (rFSH) given once daily for seven days. The ENGAGE data was presented along with data from the Phase III ENSURE trial and the Phase II REALIZE trial at the 25th annual meeting of the European Society of Human Reproduction and Embryology (ESHRE) in Amsterdam, The Netherlands.
-- 26 confirmed cases in Wales, with 9 new cases:
Researchers in Berlin, Germany have ameliorated inflammation of the brain in mice caused by immune cells.
A clinical trial is being launched in three African countries of a drug that could eliminate onchocerciasis, or river blindness, one of the leading infectious causes of blindness across Africa. The drug, moxidectin, is being investigated for its potential to kill or sterilize the adult worms of Onchocerca volvulus, which cause onchocerciasis.
There appears to be a link between sleep and weight control, with some studies indicating that sleep disruption can increase weight gain and others that diet affects sleep. Victor Uebele and colleagues, at Merck Research Laboratories, West Point, have now provided further evidence to support this association by showing that T-type calcium channels regulate body weight maintenance and sleep in mice. These data suggest that sleep and circadian treatment approaches may be of benefit in the fight against obesity.
Today"s 65 year old Medicare Part D beneficiary will be 79 when the coverage gap, or "donut hole," is eliminated, says a new analysis of proposed legislation from the House of Representatives released today by Avalere Health. The firm also concludes that although fewer people will fall into the gap from now until 2023, by 2020 some of the sickest Medicare beneficiaries will spend upwards of $16,000 on drugs before reaching catastrophic coverage where the government covers 95% of their drug costs.
A new study of obese adolescents has shown that laparoscopic gastric banding surgery -- the "Lap-Band" procedure -- not only helps them achieve significant weight loss but can also improve and even reverse metabolic syndrome, reducing their risk for cardiovascular disease and diabetes.
For the first time, scientists have shown that chromosomal abnormalities are present in more than 90% of IVF embryos, even those produced by young, fertile couples. Ms Evelyne Vanneste, a PhD student in the Centre for Human Genetics and the University Fertility Center, Leuven University, Belgium, told the 25th annual conference of the European Society of Human Reproduction and Embryology today (Wednesday July 1), that the surprising finding meant that current techniques used in preimplantation genetic screening (PGS), where embryos are screened genetically in order to select the best embryo for transfer, do nothing to improve pregnancy and live birth rates. Indeed, it can lead to potentially viable embryos being discarded, she said.
AstraZeneca announced that it has received a licence by the European Medicines Agency (EMEA) for its oral targeted anti-cancer drug, gefitinib, for EGFR (epidermal growth factor receptor-tyrosine kinase) activating mutation positive patients with Non Small Cell Lung Cancer (NSCLC). NSCLC is the most common type of lung cancer and accounts for 80% of all lung cancer cases. [1] The licence means that for the first time, thousands [2] of patients undergoing first line treatment of NSCLC in the UK may benefit from a more effective, [3] oral alternative to doublet chemotherapy (UK standard of care) without many of the side effects associated with chemotherapy. [3]
A new study by a large international consortium found that many common genetic variants contribute up to a third of a person"s risk of inheriting
UCB announced that the U.S. Food and Drug Administration (FDA) approved Cimzia®, the only PEGylated anti-TNF (Tumor Necrosis Factor), for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA). Cimzia® can be dosed at 400 mg initially and at weeks two and four, followed by 200 mg every other week; for maintenance dosing, 400 mg every four weeks can be considered.
Colorado Right to Life and Personhood USA are proposing a 2010 state ballot initiative with a different version of 2008"s defeated "personhood" amendment to the state constitution, the Colorado Springs Gazette reports. The groups intend to submit their proposal to the Colorado Legislative Council this week. In the November 2008 election, 73% of state voters opposed the previous version, known as Amendment 48, which was sponsored by Colorado for Equal Rights.The new version includes modified language that its supporters say will clarify its intent. Rather than defining a person as "any human being from the moment of fertilization," the new version would establish personhood as "every human being from the beginning of the biological development of that human being." The initiative"s sponsors also said that they will be better funded and articulate a clearer message than in 2008, when a college student launched the campaign.According to the Gazette, abortion-rights supporters "weren"t overly concerned" about the new initiative. Jacy Montoya, head of the Colorado Organization for Latina Opportunity and Reproductive Rights, said that the 2008 vote demonstrated that Colorado residents are "uncomfortable with the government and strangers making personal decision for families." Lynn Paltrow, executive director of National Advocates for Pregnant Women, said that the new attempt "gives us another opportunity to explain how personhood amendments threaten all pregnant women, including those going to term" (Barna,Colorado Springs Gazette, 6/29).
Three Republican senators took their case against Democrats" health reform to a Texas Medical Center gathering Tuesday, warning that a government insurance option is a "gateway to a single-payer system," The Houston Chronicle reports.
A new poll conducted by CNN and the Opinion Research Corporation released Wednesday says that 51 percent of people favor the president"s health reform plan while 45 percent oppose it, CNN reports.
Now that the warm weather has arrived, there"s nothing like swimming to help cool you off on a hot summer day. The American Red Cross urges everyone to make water safety a priority over the holiday weekend, whether you are taking a dip in the pool, or spending the day at the beach:
Two doctors with over 30 years of experience spoke with National Public Radio about how medicine has changed over their careers, and what they expect to see come out of the current health reform debate.
The White House sought the help of actor Ashton Kutcher to promote National HIV Testing Day on June 27, through his Twitter page, Politico reports. Kutcher has over 2.5 million followers on Twitter, where he recently posted a link to a White House blog post and video commemorating the day. Reid Cherlin, White House assistant press secretary, said, "As technology impacts how and where people are communicating online, we are constantly looking for new ways to engage with the public," adding, "Our efforts to promote National HIV Testing Day included participation from popular users of Twitter, as well as broad social media engagement by agencies across the government." The White House also used Twitter to help connect people to HIV testing sites (Gavin, 6/29).
The public was well-served today with the release of a report by the New
The UN is launching, on Wednesday the 1st of July 2009, a ten-day initiative intended to reach out to 10,000
The 2009 Neuroscience Prize of The Peter and Patricia Gruber Foundation is being awarded to Jeffrey Hall, professor of neurogenetics at the University of Maine; Michael Rosbash, professor and director of the National Center for Behavioral Genomics at Brandeis University; and Michael Young, professor and head of the Laboratory of Genetics at Rockefeller University. On October 18, at the annual meeting of the Society for Neuroscience in Chicago, Illinois, these three distinguished scientists will receive this prestigious international award for their groundbreaking discoveries of the molecular mechanisms that control circadian (daily) rhythms in the nervous system. Their research was the first to establish a simple relationship between single genes and a complex behavior.
Summer is the season for sizzling - steaks, chicken, ribs, veggie kabobs and much more. The Connecticut Department of Public Health reminds everyone that food safety is essential when grilling outdoors and offers tips to ensure that family barbecues and backyard picnics remain fun, healthy outings.
HCL plc, the UK"s largest health and social care recruitment agency, said the Government"s proposals to reform the NHS by devolving power to frontline professionals and patients will mean a greater need for flexible staffing and more collaboration between the public and private sectors.
A UK survey of 575 rheumatoid arthritis sufferers highlights the importance of maintaining independence and the significant impact that early diagnosis and treatment can have. Over 94% of those surveyed claimed that their independence was compromised in some way, with over 60% saying it was compromised significantly. With earlier treatment of their disease, nearly half of the respondents felt that they would have been more independent today, making it vital that people are aware of the significance of early intervention.
The American Dietetic Association has released an updated position paper on vegetarian diets that concludes such diets, if well-planned, are healthful and nutritious for adults, infants, children and adolescents and can help prevent and treat chronic diseases including heart disease, cancer, obesity and diabetes.
Treatment with proton pump inhibitors (PPIs) for eight weeks induces acid-related symptoms like heartburn, acid regurgitation and dyspepsia once treatment is withdrawn in healthy individuals, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.
We are all familiar with the fact that cognitive function declines as we get older. Moreover, recent studies have shown that the specific kind of daily activities we engage in during the course of our lives appears to influence the extent of this decline. A team of researchers from Technische Universitç¤t Berlin are studying how division of labour among honey bees affects their learning performance as they age. Surprisingly, they have found that, by switching their social role, aging honey bees can keep their learning ability intact or even improve it. The scientists are planning to use them as a model to study general aging processes in the brain, and they even hope that they may provide some clues on how to prevent them. Dr. Ricarda Scheiner, leader of the research team, presented these findings at the Society of Experimental Biology Annual Meeting in Glasgow.
A study in the July 1 issue of the journal SLEEP demonstrates that levels of inflammatory markers varied significantly with self-reported sleep duration in women but not men.
The U.S. Food and Drug Administration has approved Multaq tablets (dronedarone) to help maintain normal heart rhythms in patients with a history of atrial fibrillation or atrial flutter (heart rhythm disorders). The drug is approved to be used in patients whose hearts have returned to normal rhythm or who will undergo drug or electric-shock treatment to restore a normal heart beat.
The persistent cool and damp weather in the Northeast this spring put many outdoor activities on hold. With the weather finally improving, many people will head outdoors, and when they do, they are likely to find a perennial pest has been lurking, ready to latch onto the next warm-blooded body that comes by. "And that could spell serious health trouble," warns Dr. Chad Richmond, a family physician at the UDMNJ-School of Osteopathic Medicine.
Prostate cancer patients who receive brachytherapy and remain free of disease for five years or greater are unlikely to have a recurrence at 10 years, according to a study in the July 1 issue of the International Journal of Radiation Oncology Biology Physics, the official journal of the American Society for Radiation Oncology (ASTRO).
Scientists are to study a group of proteins that are highly effective at killing bacteria and which could hold the key to developing new types of antibiotics.
An OECD report has confirmed that GP-led primary care is a cost effective way to promote good health while sending a warning about the need to better promote general practice as a career. The OECD Health Data 2009 report says despite the growing need for GPs worldwide there is an increasing trend towards specialisation. The number of specialists rose by 60% between 1990 and 2007, compared with only a 23% increase in GPs.
Sen. Charles Schumer, D-N.Y., a member of the key Senate Finance Committee and advocate for a government-run health insurance plan, said yesterday he would abandon all other possible compromises in favor of immediately creating a public plan that "would operate on "a level playing field" with private insurers," CongressDaily reports. Other proposals have included a plan that would establish health insurance co-ops with government seed money or "trigger" the creation of a public plan only if private insurers fail to meet certain targets for containing costs and improving access.
Skin from a factory - this has long been the dream of pharmacologists, chemists and doctors. Research has an urgent need for large quantities of "skin models", which can be used to determine if products such as creams and soaps, cleaning agents, medicines and adhesive bandages are compatible with skin, or if they instead will lead to irritation or allergic reactions for the consumer. Such test results are seen as more meaningful than those from animal experiments, and can even make such experiments largely superfluous.