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Weight Loss In Old Age May Signal Dementia
A new study shows that older people who are thinner or are losing weight quickly are at a higher risk of developing dementia, especially if they started out overweight or obese. The research is published in the May 19, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
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Differences In Treatments And Outcomes Of Patients With Second Primary Lung Cancers Versus Those With One Primary Lung Identified
Patients with second primary lung cancers (SPLC), when compared to those with one primary lung cancer (OPLC), are more likely to have localized disease at the time of diagnosis and are more likely to receive surgical treatment rather than radiation treatment. However, patients with SPLC have a 12% higher lung cancer specific mortality, Fox Chase Cancer Center researchers reported at the annual meeting of the International Association for the Study of Lung Cancer.
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Scientists Capture The First Image Of Memories Being Made
The ability to learn and to establish new memories is essential to our daily existence and identity; enabling us to navigate through the world. A new study by researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University and University of California, Los Angeles has captured an image for the first time of a mechanism, specifically protein translation, which underlies long-term memory formation. The finding provides the first visual evidence that when a new memory is formed new proteins are made locally at the synapse - the connection between nerve cells - increasing the strength of the synaptic connection and reinforcing the memory. The study published in Science, is important for understanding how memory traces are created and the ability to monitor it in real time will allow a detailed understanding of how memories are formed.

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Also In Global Health: Text Messages For Health; Chagas Disease; Infant, Maternal Mortality In Botswana; Community Health Progs In Africa; Swaziland

UN Launches Pilot Study In Uganda That Uses Text Messages To Promote Public Health

Administration To Pitch Health Reform In "Model" Community

President Obama and top advisers will travel to Green Bay Thursday - "one of the highest-value health communities in the nation" - to promote health reform in a town-hall meeting, the Washington Post reports. "In his drive to rein in skyrocketing health-care costs, Obama is increasingly focused on wasteful medical care," the Post reports. The administration"s budget director, Peter Orszag, told the Post, "If we could make the rest of the nation practice medicine the way that Green Bay does, we would have higher quality and significantly lower costs."

Democrat Bill, FTC Examine Ways To Drive Down Health Care Costs

A bill introduced Wednesday in the House would create an artificial joints database to root out bad practices and unnecessary surgeries, The New York Times reports. "The bill, co-sponsored by (Democrats) Bill Pascrell Jr. of New Jersey and Lloyd Doggett of Texas, would establish a government-backed registry to track patients" results over time and help detect ineffective surgical practices and faulty devices. Patient registries, in areas like orthopedics, are expected to play an important role in "comparative effectiveness" reviews that the Obama administration hopes will help identify which medical procedures and products work best."

FDA Recommends Gardasil Recipients Sit, Lie Down After Receiving Vaccination

In a posting aimed at health care professionals, FDA on its Web site on Wednesday said that recipients of Merck"s human papillomavirus vaccine, Gardasil, should be closely observed afterward for 15 minutes while they remain seated or lying down to avoid the possibility of fainting, the Wall Street Journal reports. FDA said that since October 2007, Gardasil"s labeling for both health care providers and patients has included a discussion about fainting. The agency said the strengthened recommendation comes in response to reports of "traumatic injuries" among some recipients who experienced fainting (Corbett Dooren, Wall Street Journal, 6/10). Gardasil protects against the strains of HPV that cause most cases of cervical cancer and genital warts. The Centers for Disease Control and Prevention recommends that girls ages 11 and 12 receive the three-dose vaccine before they are sexually active. Girls and women ages 13 to 26 who have not been vaccinated or completed the vaccine series also should receive the vaccine (CDC fact sheet, June 2008). On Wednesday, FDA also approved changes to Gardasil materials that place warnings about fainting in a more prominent place on drug labels and handouts. The agency said that the new recommendations are intended to "prevent falls and injuries" (Wall Street Journal, 6/10).

Households Go Hungry As Financial Crisis Bites

The United Nations World Food Programme (WFP) announced the

Stroke Patients Who Have Swallowing Problems Less Likely To Develop Chest Infections Thanks To New Technology

Recovering stroke patients and others who find it hard to swallow when they eat and drink are now at a lower risk of developing pneumonia or chest infections, thanks to new technology which will help assess and treat their swallowing difficulties. Many patients suffering from stroke, head injury or major trauma often have swallowing difficulties when food and drink can go down the wrong way - patients can later develop nasty chest infections and pneumonias.

H1N1 (Swine) Flu Cases Escalate In Rhode Island, USA

The Rhode Island Department of Health (HEALTH) is seeing that H1N1 (Swine) flu continues to spread both locally and nationally. In Rhode Island, HEALTH has seen an increase in sporadic cases and outbreak clusters throughout the state, including in schools. As of 11 a.m., June 9, there are 39 confirmed positive cases in RI, doubling the case count in less than a week. Rhode Island and national surveillance data indicate increased infections in children, increased infections in individuals with chronic medical conditions, and a generally higher hospitalization rate of those infected. Although most illness in Rhode Island has been mild, compared to seasonal influenza, there is an increase in the number of hospitalizations. Ten of the Rhode Islanders with swine flu have been hospitalized.

Exercise Improves Functional And Psycological Ability And Reduces Steroid Need In Rheumatoid Arthritis

Undertaking a supervised exercise programme can have beneficial effects on functional status and physical function, reduce the need for daily corticosteroid and anti-inflammatory intake and improve levels of depression and anxiety in people with rheumatoid arthritis (RA), according to a new study presented at EULAR 2009, the Annual Congress of the European League Against Rheumatism in Copenhagen, Denmark.

Stress Makes Your Hair Go Gray

Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the June 12 issue of Cell, a Cell Press publication.

Rosiglitazone Does Not Harm Bone Healing If Combined With Metformin In Rats

Taking the diabetes medications metformin and rosiglitazone together reverses the adverse effects on bone of rosiglitazone treatment alone in an experimental model, according to a new study done in rats. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.

National Organization For Rare Disorders To Honor Rare Disease Pioneers

The National Organization for Rare Disorders (NORD) will honor a senior U.S. Senator, a top Administration official, a cutting-edge television network, and several pioneering companies developing treatments for rare diseases at the 2009 NORD Gala at the National Press Club in Washington, DC, on Thursday, May 14.

Infection Prevention Text Updated, Improved - The APIC Text Of Infection Control And Epidemiology

More than 300 infection prevention experts have completed a text that serves as one of the most valuable tools for infection preventionists throughout the world, the APIC Text of Infection Control and Epidemiology. The 1,700-page document, now in its 3rd edition, has been completely revised and is now available, offering a concise information re containing more than 120 expanded and enhanced chapters.

EULAR Highlights The Impact Of Lupus On Patients\' Lives

Results from an international online survey, carried out by UCB in conjunction with Lupus Europe and the Lupus Foundation of America, the two principal advocacy groups that represent people with lupus, were presented during the EULAR (European League Against Rheumatism) congress at a symposium called, "Lupus - considering the future."

Chance Of Fetal Complications Following Accidents Not Increased By Automobile Restraints

It is well established that seat belts save lives. However, many pregnant women do not wear seat belts, for fear that the belt itself could injure the baby in a car crash. But is this actually the case? Does the seat belt put the baby at risk?

Mylan Again Calls For An End To Authorized Generics During 180-Day Exclusivity Period

Mylan Inc."s (NASDAQ: MYL) Chief Operating Officer Heather Bresch today testified before the U.S. House of Representatives Judiciary Subcommittee on Courts and Competition Policy concerning patent litigation settlements between branded pharmaceutical companies and generic pharmaceutical companies. During her testimony, Bresch conveyed Mylan"s position that the launch of an authorized generic by brand companies during a generic company"s 180-day exclusivity period undermines competition and delays timely access to high quality, affordable generic medications for patients, taxpayers, the government and businesses.

HSPH Assistant Professor To Serve As Co-Principal Investigator Of Center In Guatemala To Combat Cardiovascular Disease

Eduardo Villamor , Assistant Professor of International Nutrition at Harvard School of Public Health (HSPH), will serve as co-principal investigator of a research and training center in Guatemala to reduce the burden of cardiovascular disease (CVD) in the Mesoamerican region, which includes Central America, the Caribbean, and Southern Mexico.

Awarepoint Announces Real-Time Location System (RTLS) Deployment To Moores Cancer Center

Awarepoint Corporation announced deployment of its Real-time Location System (RTLS) at the Rebecca and John Moores UCSD Cancer Center. This deployment adds a third UCSD Medical Center hospital to Awarepoint"s RTLS coverage, which currently includes the system"s Thornton and Hillcrest campuses. The Awarepoint enterprise RTLS installation has now been expanded to include nearly 1.5 million square feet with more than 2,000 assets under management, covering three hospitals across nearly 14 miles.

Only Half Of Brits Can Find Their Heart

UK researchers who asked over 700 patients and members of the public to pick out a diagram that showed the correct location of the human heart

Medtronic Receives FDA Approval For BRYAN(R) Cervical Disc System

Medtronic, Inc. (NYSE: MDT) announced that it received U.S. Food and Drug Administration (FDA) approval to market the BRYAN® Cervical Disc System for the treatment of single-level cervical disc disease (radiculopathy and/or myelopathy). In July 2007, Medtronic"s PRESTIGE® Cervical Disc was the first artificial cervical disc to be approved by the FDA. With the BRYAN® Disc and the PRESTIGE® Disc, Medtronic now offers a diverse portfolio of artificial cervical discs that address varying philosophies among spine surgeons about optimal implant materials, fixation methods, surgical techniques, and other unique design features.

Early Onset Of Prostate Cancer May Be Predicted By Genetic Marker

Fox Chase Cancer Center researchers have identified a genetic marker that is associated with an earlier onset of prostate cancer in Caucasian men who have a family history of prostate cancer. If the data are confirmed, the marker may help clinicians personalize prostate cancer screening.

Maricopa Integrated Health System Reports 90 Percent Reduction In Pressure Ulcers

A retrospective analysis conducted by clinicians at Maricopa Integrated Health System (MIHS) found that a protocol of care using a standardized algorithm with advanced products reduced the prevalence of pressure ulcers by 90 percent, according to data presented this week at the 41st Annual Conference of the Wound, Ostomy and Continence Nurses (WOCN) Society.(1)

Women With Breast Cancer Cope Better Following Program Focused On Body, Mind And Spirit

Pathfinders, a program designed to care for the whole person -- body, mind and spirit -- has been found to help women with terminal cancer cope and has improved their quality of life, according to a study led by researchers in the Duke Comprehensive Cancer Center.

Estrogens Do Not Protect Against Cardiovascular Death For Transsexuals

Long-term estrogen use does not protect male-to-female transsexuals from death due to cardiovascular disease but does not appear to raise their overall death rate, a new study found. The results were presented at The Endocrine Society"s 91st Annual Meeting in Washington, D.C.

Patching Gaps In Global Pneumococcal Vaccination

Since 2000, U.S. infants have been routinely immunized against pneumococcal (Streptococcus pneumoniae) infection, but the existing vaccine"s expense puts it out of reach for most developing countries, where almost one million children die from pneumococcal infections each year. Richard Malley, MD, of the Division of Infectious Diseases at Children"s Hospital Boston, is at work on a pneumococcal vaccine that meets developing countries" needs it can be made cheaply, withstands high temperatures without refrigeration, and can be given without needles, avoiding the need for sterile procedures and medical professionals to administer it. Also, because it is a whole-cell vaccine, it should provide protection against virtually all of the 91 pneumococcal serotypes that infect people worldwide. (The U.S. vaccine covers only seven.)

Asymptomatic Perioperative Myocardial Injury Affects Vascular Outcomes

A new study reports that 75 percent of cardiac damage after vascular surgery is asymptomatic or patients" symptoms are concealed by postoperative complaints such as nausea and incision pain. This damage is associated with an increased risk for mortality. Researchers have found that screening for cardiac damage following surgery helps identify high-risk patients who might benefit from more aggressive medical therapy and follow-up after discharge. These findings are from a study presented today at the 63rd Annual Meeting of the Society for Vascular Surgery®.

UK Tops The List Of 213 Countries At Extreme Risk To The Spread Of Swine Flu

A Warwick Business School professor and one of the founders of global risks specialist, Maplecroft, has released three new maps and indices revealing the countries most at risk from an influenza pandemic.

Can Light Therapy Improve Your Sexual Functioning? New Promising Data

Although we are still far from knowing exactly where and how the pineal suppressive role is exerted, the fact that the gland exerts an inhibitory function on the reproductive axis is widely accepted. In fact, the pineal seems to exert its hormonal effect at different levels of the reproductive axis, both at the hypothalamic-pituitary level and at the gonadal level, where melatonin receptors have also been found.

A Novel Communication Role For CYP17A1 In The Progression Of Castration-Resistant Prostate Cancer

UroToday.com - This publication describes our unique finding that the steroidogenic enzyme CYP17A1 is present in prostate derived exosomes, isolated from human serum. We also describe CYP17A1 expression in human prostate tissues during castration resistant progression of cancer and identify a subcellular pattern of distribution for CYP17A1 consistent with a secretory protein in human prostate tissues, similar to that of PSA.

UK Reports First Swine Flu Death

The UK reported its first death to H1N1 swine flu on Sunday after a 38-year old mother from Glasgow died in a Scottish hospital days after she

The 32nd British Transplant Games 30th July - 2nd August 2009

This year the British Transplant Games takes place in Coventry and 900 transplant athletes are preparing to take part. For a handful of these athletes, the Games offers vital training and preparation for other major sporting challenges such as triathlons and marathons. The event organisers, Transplant Sport UK shines the spotlight on these inspiring people, who visibly demonstrate that there is life after transplant, allowing them to train to a high level of fitness against all the odds.

The Doctor Will See You At The Next Window; Drive-Through Pandemic Exercise Was First In Nation

A couple of months ago, Stanford Hospital had a preview of what a real pandemic might look like: hundreds of people, fearing they might be sick with the H1N1 virus, showed up at the emergency department looking for help. Hospital officials scrambled fast, converting some space over night into an infection-controlled triage area.

Dartmouth Studies Influence Administration, Even In Choice Of Venue

When President Obama chose Green Bay, Wis., to talk about the need for health reform, he did so in part because the area has achieved a high level of quality, and compared with other parts of the country, succeeded in restraining health care costs, National Public Radio reports. "They"re certainly spending a lot less money, and they are providing care that is equal or better than the care that is provided in many other communities around the country," Elliot Fisher, a researcher at the Dartmouth Institute for Health Policy and Clinical Practice told NPR in an interview. NPR says: "Some of the research the administration is relying on comes from the Dartmouth Institute for Health Policy and Clinical Practice," which focuses on variations in health quality and costs around the country.

Nursing Shortage Eases With Recession\'s Help

"The nation"s deep recession is helping to alleviate the decade-long nursing shortage, as workers who had left the field in better times are returning in droves," the Wall Street Journal reports. The paper quotes a study, one of six papers on the nursing workforce published today in the journal Health Affairs, that found "nearly a quarter-million nurses entered the work force in 2007-08, an 18% surge that was the largest two-year increase in at least three decades." Many of them had left nursing, but "re-entered the work force to compensate for a spouse"s lost income or health benefits, the study said." The increase is "particularly remarkable at a time when the U.S. economy has shed more than six million jobs, helping to solidify the profession"s "recession-proof" image." The study found that the surge in new nurses is due to "efforts to expand nursing schools, attract more young people into the field and improve working conditions," along with an increase in the number of foreign-born nurses.

Men Hit By \'Inexplicable\' Greater Cancer Death Risk

Men are almost 40 per cent more likely than women to die from cancer, reveals a report published today (Monday) by the National Cancer Intelligence Network (NCIN) and Cancer Research UK together with the Men"s Health Forum to mark Men"s Health Week.

Queensland Researchers Help Unlock Genetic Keys To MS

New genes discovered by Australian and New Zealand researchers may hold the key to new treatments for people with multiple sclerosis (MS).

FDA Issues Public Health Advisory Regarding Levemir Insulin

The U.S. Food and Drug Administration has learned that some stolen vials of the long-acting insulin Levemir made by Novo Nordisk Inc. have reappeared and are being sold in the U.S. market. Three lots or a total of 129,000 vials of this product were stolen in all. These stolen insulin vials may not have been stored and handled properly and may be dangerous for patients to use.

A Tiny Frozen Microbe May Hold Clues To Extraterrestrial Life

A novel bacterium that has been trapped more than three kilometres under glacial ice in Greenland for over 120 000 years, may hold clues as to what life forms might exist on other planets.

Genetic Code Cracked Of Organisms Behind Fungal Disease

Scientists have unlocked the code for the building blocks of fungal organisms which are responsible for mild as well as potentially deadly infections in people.

Personnel Concepts Readies A Workplace Preparedness Kit As WHO Proclaims H1N1 Flu Pandemic

As A/H1N1 flu cases in Europe and areas outside North America mounted, the World Health Organization (WHO) raised the global threat level to 6, proclaiming the world"s first flu pandemic in 41 years. Personnel Concepts was prepared.

Obama To Ask Doctors To Back US Health Reform

President Barack Obama is seeking support from America"s doctors today as he addresses delegates at the 158th annual meeting of the American

Sinovac Completes Construction Of H1N1 Virus Seed Bank

Sinovac Biotech Ltd. (NYSE Amex: SVA), a leading developer and provider of vaccines in China, announced today that it has completed construction of the H1N1 virus seed bank necessary to produce a virus antigen.

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression In Rheumatoid Arthritis Models By Selective Inhibition Of The Immunoproteasome

Proteolix, Inc. announced that in an article published in Nature Medicine, Proteolix"s selective immunoproteasome inhibitor PR-957 was shown to block disease progression in mouse models of rheumatoid arthritis in a dose-dependent manner and to completely eliminate visible signs of disease at the highest dose. The anti-inflammatory effect induced by PR-957 was rapid and long-lasting, lowering expression of multiple inflammatory mediators, including TNF-a and IL-6. Disease regression was evident 24 hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept in a model of aggressive arthritis.

NECT Added To WHO Essential Medicines List As Combination Treatment Against Sleeping Sickness

NECT (Nifurtimox-Eflornithine Combination Therapy), a new treatment option against sleeping sickness, a fatal disease which threatens 60 million people across sub-Saharan Africa, has been added to the Essential Medicines List (EML) of the World Health Organization (WHO) based on the application submitted by the non-profit Drugs for Neglected Diseases initiative (DNDi) and supported by Epicentre and Medecins Sans Frontieres (MSF).

Tackling Dental Access Problem About More Than Numbers, Says BDA

Research published by consumer organisation Which? highlights the well-publicised problems some patients face accessing NHS dental care, according to the British Dental Association (BDA). The consumer organisation"s research indicates that, while nine out of ten people who tried to see an NHS dentist in the last two years were successful, three million people could not get an appointment.

Lawmakers Spar Over Health Reform

As the Senate Finance Committee prepares to unveil a health overhaul proposal this week, key players have been weighing in on aspects of potential legislation.

Many In Congress Hold Stakes In Health Industry

"Almost 30 key lawmakers helping draft landmark health-care legislation have financial holdings in the industry, totaling nearly $11 million worth of personal investments in a sector that could be dramatically reshaped by this summer"s debate," The Washington Post reports. The list of members includes "Congress"s most powerful leaders and a bipartisan collection of lawmakers in key committee posts." For example, Senate Majority Leader Harry Reid, D-Nev., "has at least $50,000 invested in a health-care index" (fund), and Sen. Judd Gregg, R-NH, "a senior member of the health committee, has between $254,000 and $560,000 worth of stock holdings in major health-care companies, including Bristol-Myers Squibb and Merck." The data was part of a "release of financial disclosure forms for the House and Senate" on Friday.

Protecting Kidney Function During Heart Failure

Mayo Clinic cardiology researchers have found a peptide that helps preserve and improve kidney function during heart failure, without affecting blood pressure. Earlier variations of this peptide caused blood pressure to drop limiting the potential benefits to the kidneys. The findings appear in the current Proceedings of the National Academy of Sciences.

Survey Finds More Than Half Of Metro Manila Citizens Inhale Second-Hand Smoke Every Day

Today Center for Health Development - Metro Manila (CHD-MM) and World Lung Foundation (WLF) published the first results of a survey that shows 52% of Metro Manila citizens are exposed to second-hand smoke every day in workplaces, restaurants and other public spaces. The comprehensive survey of smoking knowledge, attitudes and behavior also revealed that 74% are exposed at least once per week.

Defeating Nicotine\'s Double Role In Lung Cancer

A lung cancer treatment that inhibits nicotine receptors was shown to double survival time in mice, according to Italian researchers.

Sen. McConnell Says Filibuster Of Supreme Court Nominee Sotomayor Remains Possible

Appearing on CBS" "Face the Nation" on Sunday, Senate Minority Leader Mitch McConnel (R-Ky.) said that Senate Republicans have not ruled out a filibuster on the Supreme Court nomination of Judge Sonia Sotomayor, The Hill reports. Although McConnell acknowledged that he has "consistently opposed filibustering judges," he added that the "precedent was established" when Democrats filibustered Miguel Estrada, an appeals court nominee under former President George W. Bush. When asked to clarify his statement, McConnell added, "The Democrats have firmly established that as a precedent, but that doesn"t mean you are going to use it" (Blake, The Hill, 6/14). McConnell also said that it is "way too early to be talking about whether or not anybody opposes this nominee" (Schieffer, "Face the Nation," CBS, 6/14).According to The Hill, McConnell is the first top GOP senator to state that a filibuster is a possibility, as most other Republicans have said only that it is too early to determine if it should be an option. Republicans "face a difficult path" if they choose to filibuster Sotomayor because party members have long decried judicial filibusters, The Hill reports (The Hill, 6/14).

Louisiana Senate Committee Narrowly Approves Provider \'Conscience\' Bill

The Louisiana Senate Health and Welfare Committee on Wednesday approved a bill (H.B. 517) that would expand the ability of health care workers to refuse to provide services for moral or religious reasons, the Baton Rouge Advocate reports. The bill passed by a 3-2 vote after the addition of amendments to narrow the scope of the legislation. According to the Advocate, the bill would allow a medical worker to choose not to participate in any service "that violates his conscience," which it defines as a religious belief or moral conviction. Gov. Bobby Jindal (R) supports the legislation, as do conservative groups like the Louisiana Family Forum and the Louisiana Right to Life Federation. Several groups oppose the bill, including Planned Parenthood, the Forum for Equality, Louisiana Agenda for Children and the American Civil Liberties Union. ACLU of Louisiana"s Marjorie Esman said that the bill could "lead to all kinds of unintended consequences," based on assertions of moral and religious objections (Blum, Baton Rouge Advocate, 6/11).

\'Shortcuts\' Of The Mind Lead To Miscalculations Of Weight And Caloric Intake, Says Penn Study

Psychologists at the University of Pennsylvania have identified a cognitive shortcut, or heuristic, they call "Unit Bias," which causes people to ignore vital, obvious information in their decision-making process, points to a fundamental flaw in the modern, evolved mind and may also play a role in the American population"s 30 years of weight gain.

New Method Separates Cancer Cells From Normal Cells

The vast majority of cancer deaths are due to metastasis, the spread of cancer cells from its primary site to other parts of the body. These metastatic cells tend to move more than their non-metastatic variants but this movement is poorly understood. Scientists are studying cancer cells intently with the hope they can learn to control the movements of the dangerous cells.

Researchers Develop Key Brake For Immune Cells In Petri Dish -- Hope For Easier Organ Transplantation?

Scientists from the Helmholtz Center for Infection Research in Braunschweig, Germany and the Medical School Hannover, Germany have succeeded in treating immune cells in a way that enables them to inhibit unwanted immune reactions such as organ rejection. Their results have now been published in the current issue of the scientific journal Journal of Cellular and Molecular Medicine.

Blood-Borne Molecule Helps Regulate Blood-Vessel Integrity

Although maintaining the integrity of blood vessel walls is essential for life, well-controlled temporary leakage of blood contents through the walls of blood vessels into the tissues is a hallmark of inflammation. Although the molecule S1P is known to act on the cells that line blood vessels (endothelial cells) to regulate the permeability of blood vessel walls, the in vivo of SIP in this process remains unknown, and whether it has a role in inflammation has not been determined. In a new study, Shaun Coughlin and colleagues, at UCSF, San Francisco, have shed light on these issues, revealing that mice that lack S1P selectively in plasma (the liquid component of blood) have increased leakage from the blood vessels in response to a variety of stimuli, including inflammatory ones. As the leakage was reversed by treatment with either S1P-containing red blood cells or an agonist for the protein to which SIP binds, the authors conclude that S1P in the blood regulates blood-vessel integrity and prevents potentially lethal decreases in blood volume after exposure to leak-inducing stimuli.

Cambridge Consultants To Showcase Inhaler Design And Development Process At RDD 2009, Europe

Cambridge Consultants will be showcasing its proprietary design and development process for Dry Power Inhalers (DPIs) at the Respiratory Drug Delivery (RDD) Europe 2009 conference in Lisbon later this month.÷  The company will demonstrate its ability to move inhaler design quickly through all stages of development from concept through manufacture to final product, getting it right first time, accelerating the creation of new inhalable drug delivery devices, and offering pharmaceutical companies a quick route to market, saving up to six months in development.

Reengineering A Food Poisoning Microbe To Carry Medicines And Vaccines

Scientists have used genetic engineering to tame one of the most deadly food poisoning microbes and turn it into a potential new way of giving patients medicine and vaccines in pills rather than injections. The study is in the current issue of ACS" Molecular Pharmaceutics, a bi-monthly journal.

Pharma Enhances Patient Recruitment Methods Through Industry Site Level Dataset

KMR GROUP, a firm analyzing biopharmaceutical R&D performance since the early 1990s, announces SiteView, its newest module in the Enrollment Metrix Application. Enrollment Metrix helps companies plan more effectively and reliably when setting recruitment targets and timelines, therefore helping companies save millions of dollars due to delay and non-conformance.

American Dental Association, The Forsyth Institute Collaborate To Pilot Evidence-Based Dentistry Training Course

The American Dental Association (ADA) Center for Evidence-Based Dentistry (EBD) and The Forsyth Institute announce the offering of an intensive, five-day training course in evidence-based principles and tools, including systematic reviews and applications for clinical decision making.

Monsoon Season Will Bring Japanese Encephalitis

The 2009 monsoon season will soon arrive in the Asian territories and culicine mosquito populations are expected to increase. "These mosquitoes may carry the virus that causes Japanese Encephalitis (JE), which kills 10-15,000 people each year," warned Fran Lessans, CEO of Passport Health, the largest provider of travel medical services in the U.S. A new vaccine called Ixiaro(R) has been approved by the FDA, and is ready for distribution in the United States. Some Passport Health"s offices will have both JE-VAX(R) and Ixiaro(R) until JE-VAX(R) is phased out. "The new vaccine is good for adults over 18 so we still have to use JE-VAX(R) for the younger population," concluded Lessans. Both vaccines protect against JE.

Sparta Systems(TM) Outlines Tips And Tactics To Prepare For EMDR Mandate

Sparta Systems, Inc., the maker of TrackWise(R) software and the market leader in enterprise quality and compliance management solutions, outlined its recommendations to help companies prepare for electronic Medical Device Reporting (eMDR), the expected regulation from FDA Center for Devices and Radiological Health (CDRH). The mandate will require electronic filing of safety reports for medical device organizations.

URAC And CARF International Announce New Survey Tool For Health Care Case Management Studies

URAC, the leading health care accreditation and education organization, and CARF International, a premier, global, independent accreditor of health and human services, announced a new tool for case management professionals. The uSPEQ(R)/URAC Participant Experience Survey for Case Management (uSPEQ-CM) will help evaluate and improve the quality of health care programs and services offered to consumers.

FDA Clears Hologic R2(TM) DigitalNow(TM) HD Software Application

Hologic, Inc. (Hologic or the Company) (Nasdaq: HOLX), a leading developer, manufacturer and supplier of premium diagnostics, medical imaging systems and surgical products dedicated to serving the healthcare needs of women, announced that it has received Food and Drug Administration (FDA) clearance for its R2(TM) DigitalNow(TM) HD software application.

Measuring Brain\'s Memory Centers May Help Predict Alzheimer\'s

Scientists at the University of California, San Diego School of Medicine have shown that a fully automated procedure called Volumetric MRI which measures the "memory centers" of the brain and compares them to expected size is effective in predicting the progression from mild cognitive impairment (MCI) to Alzheimer"s disease. The procedure can be readily used in clinics to measure brain atrophy, and may help physicians to predict decline in MCI patients. Their study has been published in the June issue of the journal Alzheimer Disease and Associated Disorders.

Summer Is Time For Lightning Safety

Summer is the peak season for lightning-related injuries. When planning outdoor activities, know what shelter is available and where to go if you hear thunder.

Test Detects Molecular Marker Of Aging In Humans

In 2004, researchers at the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center announced a crucial discovery in the understanding of cellular aging. They found that as cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian organs. Because p16INK4a is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention.

Lack Of Spectacles Costs $427 Billion

Over 158 million people in the world are effectively blind because they do not have the spectacles they need to correct their vision. The cost of this disability is enormous. A recent study published in the Bull World Health Organ claims that uncorrected refractive error results in a loss of economic productivity globally worth $427 billion.

Certain Cold Remedies Linked To Loss Of Sense Of Smell Warns FDA

The US Food and Drug Administration (FDA) advised consumers yesterday not to use certain cold remedies under the Zicam label because they

Social Care Workforce Not Ready To Deliver Dementia Care - MPs

A report published revealed the social care workforce is unfit to deliver quality care for people with dementia.

The Portable PT100 Noncontact Tonometer May Offer An Accurate And Convenient Alternative To Goldmann Applanation Tonometry

The portable noncontact PT100 tonometer provides intraocular pressure (IOP) measurements comparable to Gold applanation tonometry (GAT) within the normal range of IOP, according to a new article published online in Clinical Ophthalmology (published by Dove Medical Press).

6 \'Major Health Agencies\' Form Alliance To Address Chronic Diseases In Developing Countries

A group of "major health agencies" from Australia, Canada, China, the U.K. and the U.S., which "together control 80 percent of the world"s public health-research funding," have joined together to form the Global Alliance for Chronic Diseases (GACD) to combat chronic diseases in developing countries, Time reports (Walsh, Time, 6/16).

American Society of Health-System Pharmacists Awards Viso-Gurovich Honorary Membership

The American Society of Health-System Pharmacists (ASHP) has named Fela Viso-Gurovich, Ph.D., an honorary member of the Society for her pioneering work in the development of hospital pharmacy in Mexico. Dr. Viso-Gurovich received the honor during ASHP"s Summer Meeting in Rosemont, Ill.

Founder Of The Royal Pharmaceutical Society Commemorated In Tunbridge Wells

The 150th anniversary of the death of Jacob Bell, founder of the Royal Pharmaceutical Society of Great Britain, was remembered on Friday 12 June at a ceremony at his memorial in Woodbury Park Cemetery, Royal Tunbridge Wells.

Cyclist Tackles Amazing Feat To Raise Money For The American Lung Association

It"s not every day one wakes up and decides to ride their bike from San Francisco to Washington, D.C., but if you are Shawne Camp, anything is possible. Camp suffers from an extremely painful and rare lung disease called spontaneous pneumothorax, which can cause a sudden collapse of the lung. After enduring chest tubes, surgery to essentially glue his right lung to his chest wall and countless hours of pulmonary rehabilitation, Shawne has since made a full recovery.

Strengthening The Foundation Of Social Security

The U.S. Senate Special Committee on Aging will hold a hearing on Wednesday, June 17, 2009 at 2:00 pm ET, to examine the current Social Security benefit structure, and how to strengthen and reform the program for future beneficiaries. The committee will hear from witnesses on reform ideas and how to meet our retiree and disabled citizens" needs. Today, one-third of Americans 65 years and older depend on Social Security benefits to supply 90 percent of their total income.

Income, Education, Important Factors In Heart Disease Risk

Doctors who ignore the socioeconomic status of patients when evaluating their risk for heart disease are missing a crucial element that might result in inadequate treatment, according to a University of Rochester Medical Center study published in the June 2009 American Heart Journal.

Fluidigm Introduces New TOPAZ(R) Protein Crystallization Chip That Provides A "Screen To Beam" Solution

In the rarified world of protein crystal hunters, Fluidigm"s TOPAZ® system is the tool that has helped researchers solve the structures of proteins from the Ebola Virus and Avian Flu Influenza. Now Fluidigm is introducing its new 1.96 Diffraction Capable (DC) integrated fluidic circuit which will allow researchers something they have long sought - direct screen-to-beam capabilities without the need to physically harvest a crystal from the device.

New Indicators Will Help Drive Quality Improvement In The NHS, UK

A list of more than 200 indicators of high quality care in the NHS is being published for the first time to help clinicians drive up the quality of care they deliver to patients, the Department of Health and The NHS Information Centre announced today.

ARYx Therapeutics Inc. Updates Progress With Tecarfarin EmbraceAC Study

ARYx Therapeutics Inc. (NASDAQ:ARYX), a biopharmaceutical company, announced today that the database for the EmbraceAC study has been locked and the study remains on schedule, with the efficacy and safety results to be available during the week of July 6, 2009. The study was designed to compare its oral anticoagulation therapy, tecarfarin (previously ATI-5923), against the leading anticoagulant agent, warfarin. The purpose of the trial is to evaluate whether tecarfarin is superior to warfarin in its ability to maintain patients within a target therapeutic range of the level of anticoagulation as measured by INR (International Normalized Ratio). Based upon recent interactions with the U. S. Food and Drug Administration (FDA), ARYx believes this trial could be positioned as one of the required registration studies for tecarfarin.

Another McGill/JGH Breakthrough Opens Door To Early Alzheimer\'s Diagnosis

A new diagnostic technique which may greatly simplify the detection of Alzheimer"s disease has been discovered by researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal"s Jewish General Hospital (JGH). Their results were published June 8 in the Journal of Alzheimer"s Disease. There is currently no accepted blood test for Alzheimer"s, and the diagnosis is usually based on expensive and labour-intensive neurological, neuropsychological and neuroimaging evaluations.

ChemGenex To Present Pivotal Data In T315I Positive CML Patients As Oral Presentation At ASCO

ChemGenex Pharmaceuticals Limited (ASX:CXS) (NASDAQ:CXSP) announced that updated clinical data from the registration-directed clinical trial of omacetaxine will be presented as an oral presentation at the forthcoming American Society of Clinical Oncology (ASCO) 45th Annual Meeting in Orlando, Florida.

Cells Are Like Robust Computational Systems, Carnegie Mellon-Led Team Reports

Gene regulatory networks in cell nuclei are similar to cloud computing networks, such as Google or Yahoo!, researchers report today in the online journal Molecular Systems Biology. The similarity is that each system keeps working despite the failure of individual components, whether they are master genes or computer processors.

Greater Boston Unites To Transform Health Care

A coalition of organizations representing healthcare stakeholders throughout Greater Boston has been selected by the Robert Wood Johnson Foundation (RWJF) to participate in a planning grant to become part of the Aligning Forces for Quality (AF4Q) initiative. AF4Q is the Foundation"s signature effort to lift the overall quality of healthcare in targeted communities, reduce racial and ethnic disparities, and provide models for national reform.

Structures From Immune System\'s Oldest Branch Shed Light On A Range Of Diseases

How molecules of the oldest branch of the human immune system have interconnected has remained a mystery. Now, two new structures, both involving a central component of an enzyme important to the complement system of the immune response, reveal how this system fights invading microbes while avoiding problems of the body attacking itself.

New Cortex Study Uncovers How We Recognize What Is True And What Is False

A recent neuroimaging study reveals that the ability to distinguish true from false in our daily lives involves two distinct processes. Previous research relied heavily on the premise that true and false statements are both processed in the left inferior frontal cortex. Carried out by researchers from the Universities of Lisbon and Vita-Salute, Milan, the June Cortex study found that we use two separate processes to determine the subtle distinctions between true and false in our daily lives. Deciding whether a statement is true involves memory; determining one is false relies on reasoning and problem-solving processes.

Brain Detects Happiness More Quickly Than Sadness

Our brains get a first impression of people"s overriding social signals after seeing their faces for only 100 milliseconds (0.1 seconds). Whether this impression is correct, however, is another question. Now an international group of experts has carried out an in-depth study into how we process emotional expressions, looking at the pattern of cerebral asymmetry in the perception of positive and negative facial signals.

Don\'t Forget Your Condoms At Swansea Pride, Says Terrence Higgins Trust Cymru

HIV and sexual health charity Terrence Higgins Trust (THT) Cymru is reminding visitors to Swansea Pride (Saturday 27th June) not to put their sexual health at risk by getting carried away with the party mood.

Jumping Genes Challenge Assumptions About Genetic Diseases Such As Cancer

Jumping genes do their jumping while the embryo is growing and not when sperm and eggs are developing, according to a new study by US

Do I Know You From Somewhere? How Humans Recognise Kin

Humans can tell if two strangers are related, even if they are generations apart, just by looking at their faces. So say scientists writing today in the journal Proceedings of the Royal Society B , who believe this ability helps us to interpret situations and understand the motives of others in a social setting.

American Cancer Society Forum To Address Cancer\'s Economic Impact On The Workforce

The American Cancer Society will host its inaugural Corporate Impact Conference June 18-19 in Chicago to help large corporate employers diminish the impact of cancer on the workforce and help improve workplace productivity. "Companies Changing the Course of Cancer" is designed to guide businesses in potentially lowering health care costs related to cancer and improving their overall bottom line.

Diabetes UK Pinpoints Key Research In South Asian People

Diabetes UK and the South Asian Health Foundation (SAHF) are highlighting 16 research topics in a new report to find out more about diabetes in South Asian people.

Obama Plan To Cut Hospital Payments Draws Ire

The Obama administration has called for $200 billion in cuts for hospital reimbursements in an effort to overhaul the health care system. Federal funding under the reimbursement system known as "disproportionate share payments" is provided to hospitals in large part to help meet the cost of caring for the uninsured. Administration officials argue that as the number of uninsured decrease, reimbursements should also fall. However, hospital leaders and staff worry about such cuts as well as calls for a government-run insurance plan to compete with private plans.

Insurers Refuse To Stop Canceling Some Sick Patients\' Policies

Members of Congress grilled executives from the insurance industry"s big three - UnitedHealth Group, WellPoint, and Assurant - for canceling coverage of more than 20,000 paying policy holders at a hearing Tuesday, the Los Angeles Times reports. The executives responded that they would continue the practice, known as rescission, which has saved them an estimated $300 million over a five-year period.

The Ozone Man Treats Xaverian High School To Prevent Spread Of Contaminated Swine Flu Within Its Indoor Environments

The Ozone Man, Inc. (OTCBB: OZOM), dba TOMI Environmental Solutions, or TOMIES, announced today the completion of a deep cleaning treatment of Xaverian High School with a student body of 1400 located in Brooklyn, New York. The Ozone Man"s treatment eliminated contaminants including Swine Flu "H1N1" along with inactivating viruses. The Ozone Man"s treatment also eliminates odor, mold spores and kills bacteria in the treated areas. Its proprietary Ultraviolet Ozone Generators produce the cleanest ozone south of the stratosphere, helping to ensure the health, safety and well being of the building and its inhabitants.

UN Secretary-General, World AIDS Campaign And UNAIDS Launch World AIDS Day Theme Of \'Universal Access And Human Rights\'

Ahead of this year"s World AIDS Day, the United Nations Secretary-General Ban Ki-moon, the World AIDS Campaign and the Joint United Nations Programme on HIV/AIDS (UNAIDS) have come together to announce the theme of "Universal Access and Human Rights".

Continued International Investment, Decreased Discrimination Key To Fight Against HIV/AIDS, Says U.N. Secretary-General

U.N. Secretary-General Ban Ki-Moon during a General Assembly meeting Tuesday urged governments not to cut aid for the international fight against HIV/AIDS, the AP/Washington Post reports. Even as Ban "called for "bold action" not only to increase funding but also to break down social barriers to achieve the goal set by world leaders in 2006 of universal access to comprehensive HIV prevention services, treatment, care and support by 2010," he and other speakers at the meeting "reviewing progress and challenges in the battle against AIDS indicated that it will be exceedingly difficult - if not impossible - to reach the goal" (Lederer, AP/Washington Post, 6/16).

Opinion: World Must Work Together To Stop Human Trafficking

"To some, human trafficking may seem like a problem limited to other parts of the world," Secretary of State Hillary Rodham Clinton writes in a Washington Post opinion piece, but "it occurs in every country, including the U.S., and we have a responsibility to fight it just as others do." According to Clinton, trafficking can produce "destructive effects" on "all of us," because it "weakens legitimate economies, breaks up families, fuels violence, threatens public health and safety, and shreds the social fabric that is necessary for progress." She writes that the problem is "particularly urgent now, as local economies around the world reel from the global financial crisis."

New DVD Helps Doctors Managing Difficult Issues

To support doctors who are confronted with challenging issues in medical practice, the Royal Australian College of General Practitioners (RACGP) and the Medical Practitioners Board of Victoria have developed a DVD that provides doctors with tips on managing difficult situations while maintaining their legal and ethical obligations.

Sen. Sessions To Give Floor Speeches On Judiciary As GOP Prepares For Sotomayor Debate

Sen. Jeff Sessions (R-Ala.), the ranking member on the Senate Judiciary Committee, on Wednesday is expected to outline the Republican Party"s vision for the judiciary and the kinds of judges the GOP supports for the Supreme Court in the first of a series of floor speeches, according to committee s, Roll Call reports. Although the speeches are not directly targeted at Supreme Court nominee Judge Sonia Sotomayor, Sessions said he hopes they will begin a "national dialogue" on the judiciary"s role ahead of her confirmation hearing, which is scheduled to begin July 13. Sessions is expected to give four to five speeches, which also will appear as opinion pieces in the Washington Times this week. His first speech will address his views on the foundation of a strong judiciary and judicial restraint. The later speeches will focus on President Obama"s call for judges who display "empathy" and other issues, according to Roll Call. The committee said the speeches "will address the fundamental issues that will be in play during the confirmation process" and "make the case for judicial restraint versus judicial activism."According to Roll Call, part of Sessions" motivation for giving the speeches is to clarify the definition of terms like "judicial restraint," "activist judge" and "empathy standard," phrases that frequently arise in debates over judges but might not be widely understood among judicial outsiders and the general public. Senators are expected to question Sotomayor on such topics during her confirmation hearing, and Sessions aims to define the context of the terms before the hearings begin, Roll Call reports. Senate Judiciary Committee Chair Patrick Leahy (D-Vt.) said that he is optimistic that Sotomayor"s hearings will remain bipartisan and that Republicans would not attempt to derail them by boycotting the hearings. He added that he believes GOP senators will participate in the hearings despite their complaints that they have not had enough time to prepare (Stanton, Roll Call, 6/17).

Lack Of Access To Contraception Persists In Nigeria, Study Finds

Nearly one-third of sexually active women ages 15 to 24 in Nigeria had an unmet need for modern contraception in 2003, according to a study from the Guttmacher Institute, BBC News reports. The study, which analyzed health data from Nigerian authorities and non-governmental organizations, found that 16% of pregnancies among women ages 15 to 24 in 2003 were unintended, compared with 10% in 1990. From 1990 to 2003, there was little change -- from 4% to 8% -- in use of modern contraceptives among young women who were sexually active. In addition, the proportion of sexually active young women who were aware of how to access family planning services decreased from 32% in 1990 to 18% in 2003, the study found. The study also said that although the proportion of girls and young women with some secondary education increased from 34% in 1990 to 50% in 2003, Nigerian authorities have inadequately promoted sexual health information, including contraceptive information, to the country"s youth. The report noted that Nigeria"s population is increasing by 2.2% annually and will double every 32 years if that rate is maintained.Friday Okonofua, the co-author of the report, said, "We are failing Nigerian adolescents when it comes to providing them with the information and services they need to delay marriage and avoid unintended pregnancies." She added that the lack of information leaves girls and young women vulnerable to unintended pregnancies and sexually transmitted infections like HIV (BBC News, 6/16).

Classifying Antiabortion-Rights Crimes As \'Terrorism\' Unnecessary, USA Today Opinion Piece States

Scott Roeder, who is charged with the murder of abortion provider George Tiller, and James von Brunn, who is charged with last week"s shooting death of a Holocaust Memorial Museum guard, "appear to be murderers, not terrorists," Jonathan Turley, a professor of public interest law at George Washington University, writes in a USA Today opinion piece. Although "liberals denounced" the tendency of conservatives to call "every possible crime an act of terrorism" while former President George W. Bush was in office, now that there are antiabortion-rights and anti-Semetic suspects, "there is an insistence that these crimes must be treated as terrorism -- as if to call them "murder" or "hate crimes" would diminish their significance," Turley states. Many people who "kill strangers out of hate for their race or religion or some other association" are "loners or rogue operators who seek to satisfy a blood lust against different groups," Turley contends, noting that classifying a crime as an act of terrorism allows for a different types of prosecution, investigation and punishment. According to Turley, the "term "terrorism" once had a clear meaning before it was used as a point of emphasis to evaluate or distinguish certain crimes." The Bush administration"s broadening of the definition to include "any prosecution that disrupts a "potential" terrorism threat" served to further divert the term from its historical definition, he adds. Now, "many want to see terrorism investigations targeting antiabortion activists and other groups that use violent speech," Turley writes."We do not advance our efforts by classifying every hate crime as terrorism," Turley continues, adding that it would be "the terrorists who will benefit from our lack of focus" in the definition. According to Turley, the "fact is that even an authoritarian nation can do little to stop a determined rogue operator from walking into a church and killing someone like Dr. Tiller." Referring to "someone such as Roeder as a murderer does not diminish the crime or the victim" because "we do not have to call murder "terrorism" to take the crime or its causes seriously," Turley writes (Turley, USA Today, 6/17).

Transatlantic Co-Operation Leads To Major Scientific CMOS (sCMOS) Technology Breakthrough

CMOS image sensor (CIS) technology stands on the brink of fulfilling its potential to become the global detector platform of choice for scientific photonics applications that require world class performance in the fields of sensitivity, speed, dynamic range, resolution, and field of view.

DMAA Supports 2009 Almanac Of Chronic Disease, Participates In Document\'s Release With Partnership To Fight Chronic Disease

Rising health care costs, driven by an increasing prevalence of chronic conditions, threaten the country"s place as an economic leader, Tracey Moorhead, president and CEO of DMAA: The Care Continuum Alliance, says in the 2009 Almanac of Chronic Disease.

Group Health Cooperative Shows Investing In More Primary Care Pays For Itself

An evaluation of recent innovations in delivering primary care at a Group Health Cooperative medical center shows significant success and rapid return on investment. The data led to a decision to invest in these best practices in all of Group Health"s 26 medical centers by 2010.

Does Intercessory Prayer For Sick People Actually Help Heal Them?

Health and religion have always been intertwined, most obviously through prayer on behalf of the sick. Does intercessory prayer for sick people actually help heal them? For thousands of years some people have believed so. But new Brandeis University research in the Journal of Religion this month shows that over the last four decades, medical studies of intercessory prayer - the prayer of strangers at a distance - actually say more about the scientists conducting the studies than about the power of prayer to heal.

Early Switch From Cyclosporine To Sirolimus After Renal Transplantation Produces Sustained Improvement In Renal Function

BOSTON - Favorable 12-month outcomes are maintained through 30 months of follow-up when renal transplant patients are converted from a cyclosporine (CsA)-based regimen to a sirolimus (SRL)-based regimen three months post-transplant, according to results of the CONCEPT study announced here at the American Transplant Congress (ATC) 2009.

Enzyme Doesn\'t Act Alone In Atrial Fibrillation

An overactive enzyme is behind a leaky calcium channel that plays a role in the development of atrial fibrillation, which is the most common cardiac arrhythmia that is responsible for a third of all strokes. However, it doesn"t act alone, say researchers at Baylor College of Medicine. The findings can be found online in the current edition of the Journal of Clinical Investigation.

New Study Finds That Sharing Genetic Res Key To Adaptation To Climate Change In Africa

As rapidly rising temperatures in Africa threaten to scorch local varieties of maize and other food staples, the food security of many Africans will depend on farmers in one country gaining access to climatically suitable varieties now being cultivated in other African nations, and beyond, according to a peer-reviewed study published in Global Environmental Change.